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350524

Prevalence of occult hepatitis B in southeast Asia: The first systematic review and meta-analysis

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Infectious diseases

Abstract

Background and aim: Occult hepatitis B infection is a significant public health concern in Southeast Asia. This systematic review and meta-analysis were conducted to provide detailed information on the pooled prevalence of OHB in Southeast Asia. Methods: A systematic search for articles describing the prevalence of OHB within Southeast Asian countries was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Our search returned Fifteen (15) eligible articles involving 1864 OHB cases representing Seven (7) Asian countries. A meta-analysis was performed on our eligible studies using the random effect model. A protocol was registered with PROSPERO (CRD42023422981).

Results: The pooled prevalence of OHB in southeast Asia was relatively high [10.5% (95% CI, 6.8% – 16.0%; I2 = 98.37%; p < 0.001)]. Cambodia (51.2%, CI: 48.3 – 54.0%) had the highest estimate for OHB among the Southeast Asian countries. There was a significant difference in the prevalence of OHB with the year of study and types of study designs at P < 0.001. Between 2006 and 2010, studies had the highest pooled prevalence (25.0%, CI: 12.0 – 44.8%). There was a decrease in OHB pooled prevalence at the beginning of 2011. Conclusion: The findings of this review revealed a significant prevalence of OHB in Southeast Asia (10.5%) and a fall in the incidence of OHB over the last decade in Southeast Asia. The high prevalence of OHB in Southeast Asia, despite the drop in OHB incidence within the last decades, stirs the need for effective HBV prevention.

DOI

10.21608/mid.2024.278886.1859

Keywords

Occult hepatitis B, OBI, southeast Asia, Meta-Analysis, systematic review

Authors

First Name

Kizito

Last Name

Bello

MiddleName

E

Affiliation

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia, Department of Microbiology, Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria

Email

kizzitobello@gmail.com

City

-

Orcid

-

First Name

Itodo

Last Name

Janefrancis

MiddleName

Kelechi

Affiliation

Department of Microbiology, Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria

Email

-

City

-

Orcid

-

First Name

David

Last Name

Zakari

MiddleName

Adeiza

Affiliation

Department of Microbiology, Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria

Email

david.z@ksu.edu.ng

City

Anyigba

Orcid

0000-0002-7111-6065

First Name

Saliu

Last Name

Modupe

MiddleName

Hadiya

Affiliation

Department of Microbiology, Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria

Email

-

City

-

Orcid

-

First Name

Aishat

Last Name

Musa

MiddleName

-

Affiliation

Department of Microbiology, Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria

Email

aishatoizamusa@gmail.com

City

-

Orcid

-

First Name

Irekeola

Last Name

Ahmad

MiddleName

Adebayo

Affiliation

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia, Microbiology Unit, Department of Biological Sciences, College of Natural and Applied Sciences, Summit University Offa, Offa 4412, Kwara State, Nigeria

Email

-

City

-

Orcid

-

First Name

Wada

Last Name

Yusuf

MiddleName

-

Affiliation

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia, Department of Zoology, Faculty of Life Sciences, Ahmadu Bello University, Zaria 810211, Nigeria

Email

-

City

-

Orcid

-

First Name

Otuyelu

Last Name

Olakunle

MiddleName

frank

Affiliation

Department of Microbiology, University of Ilorin, Ilorin, Nigeria

Email

-

City

-

Orcid

-

First Name

Azeez

Last Name

Ridwan

MiddleName

-

Affiliation

Department of Microbiology, University of Ilorin, Ilorin, Nigeria

Email

azeez.rt@unilorin.edu.ng

City

-

Orcid

-

First Name

Jegede

Last Name

Raphael

MiddleName

-

Affiliation

Department of Biochemistry, Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria

Email

jegederaphael@gmail.com

City

-

Orcid

-

First Name

Yusuf

Last Name

Lamidi

MiddleName

-

Affiliation

Department of Biological Sciences, Kogi State University, Kabba, Nigeria

Email

loyusuf@ksukabba.edu.ng

City

-

Orcid

-

First Name

Hanim

Last Name

Rafidah

MiddleName

-

Affiliation

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

Email

hanimshueb@gmail.com

City

-

Orcid

-

First Name

Nazri

Last Name

Mustaffa

MiddleName

-

Affiliation

Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia, Hospital Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia

Email

nazri.mustaffa@usm.my

City

-

Orcid

0000-0003-3534-6717

Volume

5

Article Issue

3

Related Issue

49567

Issue Date

2024-08-01

Receive Date

2024-03-23

Publish Date

2024-08-01

Page Start

991

Page End

1,006

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 5_Issue 3_Pages 991-1006.pdf

PDF . 970.5kB

Link

https://mid.journals.ekb.eg/article_350524.html

Detail API

https://mid.journals.ekb.eg/service?article_code=350524

Order

12

Type

Systematic review or meta-analysis

Type Code

1,161

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Prevalence of occult hepatitis B in southeast Asia: The first systematic review and meta-analysis

Details

Type

Article

Created At

25 Dec 2024