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The effects of probiotic <i>Lactobacillus acidophilus</i> and colchicine on the control of symptoms, duration, and disease progression of mild and moderate cases of COVID-19: Ran

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Infectious diseases

Abstract

Background: Coronavirus disease 2019 (COVID-19) is a newly emerging human disease caused by a novel coronavirus, causing a global pandemic crisis. Probiotics and/or colchicine may be considered as options for treatment since they have anti-viral, anti-inflammatory, and immunomodulatory effects. Results: A total of 150 patients with mild and moderate severity of COVID-19 were enrolled in the study, 50 patients in each arm; around one third (34.7%) of the participants were aged between 29 and 39 years; one-quarter (24.7%) were aged between 18 and 28 years and 40.6% were aged 40 years and above. The mean duration of symptoms improvement was 12, 11 and 12 in the colchicine, probiotic, and control groups, respectively. Improvement of inflammatory markers over time occurred in each of the three groups, with no statistically significant difference between them. Conclusion: Probiotic Lactobacillus acidophilus and colchicine shows no significant effect on the symptoms, duration, and progression of mild and moderate cases of COVID-19.

DOI

10.21608/mid.2024.281579.1877

Keywords

COVID-19, RCT, Ain Shams university, Cairo

Authors

First Name

Samar

Last Name

Hassan

MiddleName

Osama

Affiliation

Family Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

dr.samar.osama@med.asu.edu.eg

City

Cairo

Orcid

-

First Name

Ahmed

Last Name

Hassan

MiddleName

Nour El-Din

Affiliation

Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Clinical Pharmacology Department, Faculty of Medicine, Galala University, Egypt

Email

ahmed.hassan@gu.edu.eg

City

Cairo

Orcid

-

First Name

Manal

Last Name

Mohamed

MiddleName

Sabry

Affiliation

Internal Medicine department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

m.sabry@med.asu.edu.eg

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

Al Ashram

MiddleName

Nabil Badawy

Affiliation

Internal Medicine department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

mohamed.elashram@ymail.com

City

Cairo

Orcid

-

First Name

Mina

Last Name

Nesim

MiddleName

Michael

Affiliation

Internal Medicine department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

minamichaelnesim@yahoo.com

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

Allam

MiddleName

Farouk

Affiliation

Family Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

farouk.allam@med.asu.edu.eg

City

Cairo

Orcid

0000-0001-5954-8909

Volume

5

Article Issue

3

Related Issue

49567

Issue Date

2024-08-01

Receive Date

2024-04-04

Publish Date

2024-08-01

Page Start

901

Page End

910

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 5_Issue 3_Pages 901-910.pdf

PDF . 642.4kB

Link

https://mid.journals.ekb.eg/article_352344.html

Detail API

https://mid.journals.ekb.eg/service?article_code=352344

Order

4

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

The effects of probiotic <i>Lactobacillus acidophilus</i> and colchicine on the control of symptoms, duration, and disease progression of mild and moderate cases of COVID-19: Ran

Details

Type

Article

Created At

25 Dec 2024