Beta
ManageSearchChatDiscover
294547

Bacteriophage therapy in diabetic foot ulcer caused by <i>Pseudomonas aeruginosa</i>.

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Bacteriophages are viruses that are used to destroy bacteria without harming host cells. As a result, it is thought that they can be used to treat bacterial infections alone or in conjunction with antibiotics. Pseudomonas aeruginosa, a multidrug-resistant bacterial pathogen, is one of the most prevalent infections in diabetic foot ulcers and has a high fatality rate. This bacterium produces a biofilm that causes recurring infections that are antibiotic-resistant and causes severe tissue damage with varying levels of severity. In this review, the role of bacteriophage therapy in diabetic foot ulcers, their advantages, limitation, and future perspectives will be discussed. The bacteriophage therapy to combat antibiotic-resistant bacteria is quite appealing, and some study data suggests that it could be a reasonable solution to overcome severe bacterial infections which cannot be treated by antibiotics. Some studies revealed that bacteriophage can be combined with antibiotics and used for effective treatment. However, phage therapy application in human treatment is scanty because the concurrent and underlying mechanism of this strategy is ambiguous among clinicians.  Additionally, there are still problems with how to create formulas for standardized and therapeutic use in bacterial control. More study that is specifically devoted to resolving these problems is necessary before bacteriophages can be used in humans. Bacteriophage therapy will be a better choice for treating diabetic foot ulcers once everything has been cleaned up, and the incidence of amputation can be decreased by bacteriophage therapy.

DOI

10.21608/mid.2023.201469.1490

Keywords

diabetic foot ulcer, bacteriophage, Pseudomonas aeruginosa, and Antibiotic resistance

Authors

First Name

Aravind

Last Name

Sasi

MiddleName

C

Affiliation

Department of Microbiology, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India.

Email

aravindchakkulangara@gmail.com

City

-

Orcid

0000-0003-1202-2015

First Name

Kavitha

Last Name

K

MiddleName

C

Affiliation

Department of Microbiology, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India.

Email

kavitha.kanniyan@avmc.edu.in

City

-

Orcid

0000-0003-4837-5824

First Name

Thiyagarjan

Last Name

sanjeevi

MiddleName

C

Affiliation

Multi-Disciplinary Centre for Biomedical Research, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India

Email

thiyagarajan.sanjeevi@avmc.edu.in

City

Pondicherry

Orcid

0000-0002-4006-7184

First Name

Ravikumar

Last Name

Sambandam

MiddleName

C

Affiliation

Multi-Disciplinary Centre for Biomedical Research, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India

Email

ravikumar.sambandam@avmc.edu.in

City

Pondicherry

Orcid

0000-0001-7351-0421

First Name

Aarthi

Last Name

Manoharan

MiddleName

-

Affiliation

Multi-Disciplinary Centre for Biomedical Research, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India

Email

aarthi.manoharan@avmc.edu.in

City

Pondicherry

Orcid

0000-0003-2318-2786

First Name

Aboobacker

Last Name

A

MiddleName

p

Affiliation

Department of Microbiology, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India.

Email

aboo869@gmail.com

City

Pondicherry

Orcid

0000-0002-2066-597X

First Name

Latha

Last Name

R

MiddleName

-

Affiliation

Department of Microbiology, Aarupadai veedu Medical College and Hospital, Vinayaka Missions Research Foundation (DU), Kirumampakkam, Puducherry-607403, India.

Email

latha.ragunathan@avmc.edu.in

City

Pondicherry

Orcid

0000-0003-2572-2678

Volume

5

Article Issue

2

Related Issue

47401

Issue Date

2024-05-01

Receive Date

2023-03-21

Publish Date

2024-05-01

Page Start

612

Page End

624

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 5_Issue 2_Pages 612-624.pdf

PDF . 917.5kB

Link

https://mid.journals.ekb.eg/article_294547.html

Detail API

https://mid.journals.ekb.eg/service?article_code=294547

Order

19

Type

Review Article

Type Code

1,160

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Bacteriophage therapy in diabetic foot ulcer caused by <i>Pseudomonas aeruginosa</i>.

Details

Type

Article

Created At

25 Dec 2024