The most encouraging approach of struggling COVID-19 and limiting the course of this pandemic was certainly the universal vaccination of the population with safe and effective vaccines. As mass vaccination initiatives against COVID-19 ensued, adverse reactions began emerging. The current case series illustrated eleven (11) patients who presented with neurological sequelae after receiving different types of COVID vaccine. This was not the first case series that discusses post COVID-19 vaccine neurological problems worldwide but rare in Egypt. These case series included five (5) cases had cerebrovascular accident, two (2) cases presented with encephalitis, and only one was diagnosed as a central retinal vein occlusion; and another one had new onset seizure; meanwhile, headache was diagnosed in two (2) cases.  It was suggested that after SARS-CoV-2 vaccination, a reactivation of the immune system causes neurological symptoms. However, further research was merited to provide more visions into this hypothesis drawn in this study.