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Comparing antibiotic susceptibility profiles of urinary tract infection isolates in a University Hospital in Burkina Faso: Community vs. hospital profiles

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Antimicrobial resistance

Abstract

Background: The emergence of antimicrobial resistance (AMR) within bacterial pathogens necessitates a local comprehension of the epidemiological context. This information is indispensable for both clinical therapeutic determinations and the reevaluation of prevailing care protocols. This study aimed to highlight the antibiotic susceptibility profile of uropathogenic bacteria isolated within a university hospital in Burkina Faso, with a focus on enhancing probabilistic antibiotic therapy for both community and hospital-based urinary tract infections (UTIs). Methodology: Data from cytological urine analysis and antimicrobial susceptibility testing spanning 29 months (January 2017 to May 2019) was retrospectively collected and systematically analyzed. Results: In both hospital and community based UTIs, Enterobacterales dominated, constituting 79.86% (81.27% vs. 79.11%) of isolates. This was followed by non-fermentative Gram-negative bacteria at 6.60% (6.35% vs. 6.88%) and Gram-positive cocci at 6.41% (7.98% vs. 5.57%). Escherichia coli (61.37%), Klebsiella pneumoniae (10.66%), and Enterobacter spp. emerged as the predominant pathogens in the same rank regardless of the origin of the ITUs. Imipenem (97.19%), amikacin (69.26%), ceftriaxone (58.44%), and ciprofloxacin (47.60%) displayed superior susceptibility against all uropathogens. Subtle but significant variations emerged between hospital and community strains' susceptibility to various antibiotics, including amoxicillin + clavulanic acid (26.05% vs. 32.26%), Imipenem (96.43% vs. 98.59%), and ciprofloxacin (45.51% vs. 51.41%). Conclusion: Penicillins showcased diminished efficacy against uropathogens, while resistance to fluoroquinolones escalated. The combined use of aminoglycosides and third-generation cephalosporins holds promise as an optimal probabilistic therapy for UTIs. Notably, the profiles of hospital and community UTIs showed substantial similarities in terms of implicated uropathogens, yet hospital strains demonstrated higher resistance levels.

DOI

10.21608/mid.2023.228523.1587

Keywords

antibiotics, resistance, uropathogens, Bobo-Dioulasso

Authors

First Name

NAGALO

Last Name

Andre

MiddleName

-

Affiliation

Sourô Sanou University Hospital, Laboratory of Bacteriology-Virology, 01 BP 676, Bobo-Dioulasso, Burkina Faso, Regional University Hospital of Ouahigouya, Laboratory of Biomedical Analysis, 01 BP 36, Ouahigouya, Burkina Faso, 10- University of Montpellier, 163 rue Auguste Broussonnet 34090 Montpellier, France

Email

nagaloandre@gmail.com

City

Ouahigouya

Orcid

0000-0002-7862-7634

First Name

KABORE

Last Name

Odilon

MiddleName

Dieudonné

Affiliation

Sourô Sanou University Hospital, Laboratory of Bacteriology-Virology, 01 BP 676, Bobo-Dioulasso, Burkina Faso, NAZI BONI University, 01 BP 1091, Bobo-Dioulasso, Burkina Faso

Email

odilonjagger@gmail.com

City

Bobo-Dioulasso

Orcid

0000-0001-8737-4555

First Name

Kissou

Last Name

Aimée

MiddleName

Senkaye-Lagom

Affiliation

Sourô Sanou University Hospital, Department of Pediatrics, 01 BP 676, Bobo-Dioulasso, Burkina Faso, NAZI BONI University, 01 BP 1091, Bobo-Dioulasso, Burkina Faso

Email

aimekissou@yahoo.fr

City

Bobo-Dioulasso

Orcid

0000-0002-1613-5669

First Name

Mahamoud

Last Name

Ali

MiddleName

Issaka

Affiliation

Adam Barak University of Abéché, 02 BP 1173, Abéché, Tchad

Email

kombotchy07@yahoo.com

City

Abéché

Orcid

-

First Name

KABRE

Last Name

Boukary

MiddleName

-

Affiliation

Department of Urology-Andrology, Tenkodogo Regional Hospital Center, 01 BP 56, Tenkodogo, Burkina Faso

Email

kabreb2000@yahoo.fr

City

Tenkodogo

Orcid

-

First Name

Semde

Last Name

Aoua

MiddleName

-

Affiliation

Sourô Sanou University Hospital, Department of Nephrology-Hemodialysis, 01 BP 676, Bobo-Dioulasso, Burkina Faso, NAZI BONI University, 01 BP 1091, Bobo-Dioulasso, Burkina Faso

Email

semdaoua@yahoo.fr

City

Bobo-Dioulasso

Orcid

-

First Name

Ouattara

Last Name

Ahmed

MiddleName

Cheick

Affiliation

Sourô Sanou University Hospital, Department of Information, Epidemiology, Research and Planning, 01 BP 676, Bobo-Dioulasso, Burkina Faso, NAZI BONI University, 01 BP 1091, Bobo-Dioulasso, Burkina Faso

Email

ouattaracheickahmed@gmail.com

City

-

Orcid

0000-0002-1014-2171

First Name

Sawadogo

Last Name

Yacouba

MiddleName

-

Affiliation

Sourô Sanou University Hospital, Laboratory of Bacteriology-Virology, 01 BP 676, Bobo-Dioulasso, Burkina Faso

Email

yac_saw@yahoo.fr

City

Bobo-Dioulasso

Orcid

0000-0003-1813-5707

First Name

ZOUNGRANA

Last Name

Jacques

MiddleName

-

Affiliation

Sourô Sanou University Hospital, Department of Infectious Diseases, 01 BP 676, Bobo-Dioulasso, Burkina Faso, NAZI BONI University, 01 BP 1091, Bobo-Dioulasso, Burkina Faso

Email

zojacques@yahoo.fr

City

Bobo-Dioulasso

Orcid

0000-0002-9397-5901

First Name

Poda

Last Name

Armel

MiddleName

-

Affiliation

Sourô Sanou University Hospital, Department of Infectious Diseases, 01 BP 676, Bobo-Dioulasso, Burkina Faso, NAZI BONI University, 01 BP 1091, Bobo-Dioulasso, Burkina Faso

Email

armelpoda@yahoo.fr

City

Bobo-Dioulasso

Orcid

0000-0002-7463-9179

First Name

Godreuil

Last Name

Sylvain

MiddleName

-

Affiliation

Arnaud de Villeneuse University Hospital, Bacteriology Laboratory, 34 295 Montpellier Cedex 5, France, University of Montpellier, 163 rue Auguste Broussonnet 34090 Montpellier, France

Email

s-godreuil@chu-montpellier.fr

City

MONTPELLIER

Orcid

0000-0003-3436-0082

First Name

Ouedraogo

Last Name

Abdoul-Salam

MiddleName

-

Affiliation

Sourô Sanou University Hospital, Laboratory of Bacteriology-Virology, 01 BP 676, Bobo-Dioulasso, Burkina Faso, NAZI BONI University, 01 BP 1091, Bobo-Dioulasso, Burkina Faso

Email

abdousal2000@yahoo.fr

City

Bobo-Dioulasso

Orcid

0000-0002-8539-3768

Volume

5

Article Issue

1

Related Issue

45807

Issue Date

2024-02-01

Receive Date

2023-08-12

Publish Date

2024-02-01

Page Start

314

Page End

323

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 5_Issue 1_Pages 314-323.pdf

PDF . 810.8kB

Link

https://mid.journals.ekb.eg/article_325571.html

Detail API

https://mid.journals.ekb.eg/service?article_code=325571

Order

33

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Comparing antibiotic susceptibility profiles of urinary tract infection isolates in a University Hospital in Burkina Faso: Community vs. hospital profiles

Details

Type

Article

Created At

25 Dec 2024