Sepsis is a complex inflammatory response that is strongly associated with multiple organ dysfunctions and considered as a major cause of morbidity and mortality worldwide. The early recognition of the causative agents of sepsis events is crucial and must be include accuracy when planning about standard and rapid laboratory procedures. To reduce the risk of death, prior studies relied on a variety of strategies, including cultural, immunological, and molecular methods for the early and precise management of sepsis. However, the mortality rate of sepsis is still high and there are not any predictive biomarkers for sepsis that may be used in clinical settings. The current study was interested in explaining the major role of some common parameters that were followed in clinical settings to improve the diagnosis of infectious agents before the cases of illnesses become complicated.  The gold standard blood culture along with complete blood count (CBC), lactate dehydrogenase (LDH), C-reactive protein (CRP), procalcitonin (PCT), presepsin (PSN), pentraxin3 (PTX3), and monocyte chemoattractant protein-1(MCP-1) could detect the microbial bloodstream infection.