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Fecal carriage rates Of extended-spectrum Β-lactamase-producing <i>Escherichia coli</i> of inpatients and outpatients attending Yobe State Teaching Hospital, Damaturu, Nigeria.

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Antimicrobial resistance

Abstract

Background: Extended-spectrum β-lactamases-producing Escherichia coli has been on rise and its infection is becoming difficult to treat. These resistant bacteria can colonize human gastrointestinal tract and can easily be spread in population. The aim of this study was to assess the fecal carriage rates of extended spectrum beta lactamase-producing E. coli (ESBL) among hospitalized and out-patients.  Methods: A total of 200 volunteers participated in the study. A stool sample was collected from each participant and subjected to standard microbiological methods for the isolation of E. coli. Furthermore, the isolates were subjected to phenotypic detection of ESBL using double-disk synergy test. The confirmatory test was performed with CAZ (30μg), CTX (30μg) and CRO (30μg) around Augmentin disc (AMC 30μg) and clear zone of inhibitions towards the AMC (30μg) considered as positive results for production of ESBL. Basic demographic information were recorded. Results: From the 200 fecal samples collected, all tested positive for E. coli. 108 females participated which represents (54%) while 92 males participated which represents (46%) and their age group ranges between 21years to 40years (n =94/200; 47%). Among the participants, 113/200 (56. 5%) were out-patients while 87/200 representing 43.5% were hospitalized patients. In this study, 116/200 (58%) of the 200 volunteers were found to harbored E. coli producing ESBL. In this study, age, gender, and hospitalization status play role in fecal carriage rates of ESBL-producing E. coli.  Conclusion: The results of this study reveal high fecal colonization of ESBL-producing E. coli. Therefore, there is need for prudent use of antibiotics among hospitalized and out-patientsز

DOI

10.21608/mid.2023.182614.1432

Keywords

extended-spectrum beta lactamase, E. coli, Antibiotic resistance, Fecal Carriage, Nigeria

Authors

First Name

Adam

Last Name

Mustapha

MiddleName

-

Affiliation

Department of Microbiology, Faculty of Science, University of Maiduguri, Nigeria.

Email

adadmustapha@unimaid.edu.ng

City

Maiduguri

Orcid

0000-0001-7218-8741

First Name

Obi

Last Name

Chidiebere

MiddleName

-

Affiliation

Department of Microbiology, Faculty of Science, Federal University Birnin Kebbi, Kebbi State, Nigeria

Email

obi.chidiebere@fubk.edu.ng

City

Birnin Kebbi

Orcid

0000-0002-2326-0097

First Name

Mari

Last Name

Bata

MiddleName

-

Affiliation

Department of Microbiology, Faculty of Science, Federal University Birnin Kebbi, Kebbi State, Nigeria

Email

bata.mari@fubk.edu.ng

City

Birnin Kebbi

Orcid

0000-0002-3939-9827

First Name

Zenoh

Last Name

Ali

MiddleName

Danjuma

Affiliation

Department of Medical Laboratory Science, Faculty of Health Sciences, Taraba State University Jalingo

Email

zenoh.d@tsuniversity.edu.ng

City

Jalingo

Orcid

0000-0002-2496-8548

First Name

Fasogbon

Last Name

Victor

MiddleName

Ilemobayo

Affiliation

Department of Biochemistry, Kampala International University Western Campus, Ishaka, Uganda

Email

ivfasogbon@kiu.ac.ug

City

Ishaka

Orcid

0000-0003-4362-9004

First Name

Micheal

Last Name

Yakubu

MiddleName

Nosano

Affiliation

Department of Microbiology, Faculty of Science, Federal University Wukari, Taraba State

Email

nosano.yakubu@fuwukari.edu.ng

City

Jalingo

Orcid

0000-0002-7998-1256

First Name

Nuhu

Last Name

Tanko

MiddleName

-

Affiliation

Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University Sokoto

Email

nuhu.tanko@udusok.edu.ng

City

Sokoto

Orcid

0000-0001-9865-0463

First Name

Alegbe

Last Name

David

MiddleName

Sunday

Affiliation

Department of Microbiology, Faculty of Life Science, Ahmadu Bello University Zaria.

Email

sunday.davidmails@gmail.com

City

Zaria

Orcid

0000-0002-9181-0230

Volume

4

Article Issue

4

Related Issue

43799

Issue Date

2023-11-01

Receive Date

2022-12-22

Publish Date

2023-11-01

Page Start

1,173

Page End

1,177

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 4_Pages 1173-1177.pdf

PDF . 703.8kB

Link

https://mid.journals.ekb.eg/article_288662.html

Detail API

https://mid.journals.ekb.eg/service?article_code=288662

Order

14

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Fecal carriage rates Of extended-spectrum Β-lactamase-producing <i>Escherichia coli</i> of inpatients and outpatients attending Yobe State Teaching Hospital, Damaturu, Nigeria.

Details

Type

Article

Created At

25 Dec 2024