Gastroenteritis is a frequent pathology in developing countries. Etiological causes include viral, bacterial or even parasitic pathogens. Implication of pancreas in acute gastroenteritis is not a common event. A female patient arrived at the emergency room of the infectious disease service with fever, nausea/vomiting, profuse diarrhea, fatigue, weakness and severe epigastric pain. From the physical and laboratory examination, the patient was conscious, with epigastric abdominal pain and temperature 39°C. Laboratory examinations resulted in an increase of white blood cells, CRP threefold of normal range, pancreatic amylase and lipase over than threefold too. The abdominal ultrasonography and computed tomography (CT) scan showed pancreatic oedema. Stool culture and antibiogram showed a multi-sensitive Salmonella enterica (S. enterica) subsp < em> enterica. Based on the 2012 Atlanta Classification of Acute Pancreatitis: abdominal pain, serum lipase activity (or amylase) at least 3 times greater than the upper limit of normal and characteristic findings of acute pancreatitis on CT or magnetic resonance imaging the case was classified as an acute pancreatitis by S. enterica subsp < em> enterica. The aim of this paper is to present a case of acute gastroenteritis from S. enterica subsp enterica complicated with acute pancreatitis.