The World Health Organization's recent declarations that COVID-19 and Mpox (previously known as monkeypox) are no longer public health emergencies of international concern marks a significant shift in the global health landscape. This commentary provides an examination of the implications of these declarations, highlighting the residual effects of these diseases on global health systems, the persistent risks they pose, and the potential impacts on health equity and access to healthcare. It further explores the indispensable role of epidemiology in informing public health policy and practices. The piece outlines a strategic approach for the future of global health, emphasizing the urgency to fortify health diplomacy, reform global health financing, harness digital health, invigorate health workforce development, implement multisectoral action, integrate climate change into health policy, mainstream mental health, and leverage precision public health. As we transition from crisis response to sustained disease management, this commentary underscores the need for unwavering commitment, international collaboration, and innovative thinking to navigate this new phase in global health.