Background:  Human Monkeypox is a zoonotic disease. The Monkeypox virus belongs to the orthopoxvirus family, and it is a double-stranded DNA virus which is mainly found among rodents and other animals and is expected to have been transmitted incidentally to humans and is further spread through human-to-human transmission. Aim: To give a clear picture of the extent of the monkeypox virus and thereby depict the future risk of community transmission of the virus. Methods: A descriptive study has been conducted by analyzing secondary data from the Centre of Disease Control, UK and the cumulative cases and deaths are calculated. This is an evidence basis analysis which describes a clear picture of the arising risk due to the monkeypox virus. Result: It was identified that data collected from reliable sources give a clearer picture of the prevalence of the monkeypox virus among men. Conclusion: With the current knowledge of the devastation caused by the COVID-19 pandemic, it is crucial to examine pathophysiology and transmission to prevent its effect on public health and its propensity to spread like a pandemic. All the governments, health agencies and organizations along with related stakeholders must work on prevention policies to control monkeypox.