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297826

Zinc level in COVID-19 Infection; Truth or myth?

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Infectious diseases

Abstract

Background: COVID-19 is accompanied by a systemic hyperinflammatory reaction and thromboembolic consequences. Zinc has antiviral, anti-inflammatory, and antioxidant properties. Moreover, zinc deficiency adversely affects immune cells' survival and function. Although it is uncertain if COVID-19 individuals lack zinc, zinc administration is used in treatment. We aimed to determine if there is a change in zinc levels in COVID-19 individuals and the relationship between zinc levels and illness severity and outcome. Methods: Sixty individuals with COVID-19 infection verified by PCR were recruited. Patients' demographics, degree of illness at the time of blood specimen, and prognosis were gathered. The zinc level in serum was measured in the first 72 hours of admission, using a cutoff for normal zinc levels between 70.6 and 114 g/dl for women and 72.6 and 127 g/dl for men. Results: Sixty individuals with an average age of 50.7 + 14.41 years were enrolled in the study; 51.7% were males, 60% were diabetics, 73% had hypertension, and 35% had obesity, where BMI was above 30 kg/m2. Regarding the COVID-19 severity, the percentage was 28.3%, 50%, and 21.7% for mild, moderate, and severe cases, respectively. There was a high prevalence of zinc deficiency; about 87% (n=52) of the patients had below-normal zinc values. The median zinc level was 39.5 (20.5-58) μg/dl. No statistically significant association was observed between blood zinc levels and illness severity or prognosis. Conclusion: Zinc insufficiency might be a risk component for the incidence of COVID-19 infection. Nevertheless, it seems unrelated to the disease course or outcome.

DOI

10.21608/mid.2023.196286.1478

Keywords

zinc, SARS-CoV-2, pneumonia, COVID-19

Authors

First Name

Zeinab

Last Name

Soliman

MiddleName

Abdellatif

Affiliation

Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

zynabelkhateb@gmail.com

City

-

Orcid

0000-0002-4468-493X

First Name

Rasha

Last Name

Abdalaziz

MiddleName

Ahmed

Affiliation

Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University.

Email

rasha7019@yahoo.com

City

-

Orcid

-

First Name

Aya

Last Name

Alsharif

MiddleName

-

Affiliation

Endemic Medicine Department, Faculty of Medicine, Cairo University

Email

ayaelshreef1@gmail.com

City

-

Orcid

-

First Name

Yasmine

Last Name

Gaber

MiddleName

-

Affiliation

Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

dr.yaso2008@yahoo.com

City

-

Orcid

-

First Name

Reem

Last Name

El-Korashy

MiddleName

Ibrahim Mohamed

Affiliation

Pulmonary Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

reem.elkorashy@kasralainy.edu.eg

City

-

Orcid

-

First Name

Youssef

Last Name

Soliman

MiddleName

Mohamed Amin

Affiliation

Pulmonary Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

ymasoliman@yahoo.com

City

-

Orcid

-

First Name

Manal

Last Name

Kamal

MiddleName

Mohamed

Affiliation

Clinical and Chemical Pathology department, Faculty of Medicine, Cairo University,Egypt.

Email

manalmk@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Hashem

MiddleName

-

Affiliation

National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt

Email

ahashem200@gmail.com

City

-

Orcid

-

First Name

Hanan

Last Name

Zaghla

MiddleName

-

Affiliation

Critical Care Medicine Department, Faculty of Medicine, Cairo University

Email

hananzaghla410@gmail.com

City

-

Orcid

-

First Name

Khaled

Last Name

Salem

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Cairo University

Email

khaledsalem@kasralainy.edu.eg

City

-

Orcid

-

First Name

Hala

Last Name

Ramadan

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Cairo University

Email

halaramadan31@yahoo.com

City

Cairo

Orcid

0000-0003-3201-5429

Volume

4

Article Issue

3

Related Issue

42578

Issue Date

2023-08-01

Receive Date

2023-03-02

Publish Date

2023-08-01

Page Start

735

Page End

740

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 3_Pages 735-740.pdf

PDF . 790.6kB

Link

https://mid.journals.ekb.eg/article_297826.html

Detail API

https://mid.journals.ekb.eg/service?article_code=297826

Order

5

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Zinc level in COVID-19 Infection; Truth or myth?

Details

Type

Article

Created At

25 Dec 2024