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293154

Association between severity of asthma and fungal sensitization in severely asthmatic patients

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Medical mycology

Abstract

Background: Fungal sensitization is usually associated with increased asthmatic severity, morbidity and mortality, including higher rates of hospital and intensive care admission. However, the possible association between fungal airway colonization with regard to sensitization remains controversial. Objectives: to investigate the presence of severe asthma with fungal sensitization among asthmatic patients and to find evidence of Aspergillus fumigatus (A. fumigatus) role in severely asthmatic patients. Methods: this study investigated forty asthmatic patients and twenty controls. Demographic data of all subjects within the study was collected, as well as total serum IgE, A.fumigatus specific IgE and A. fumigatus galactomannan antigen ELISA test. Results: our results showed significant elevation of total IgE, Aspergillus specific IgE and A. fumigatus galactomannan antigen in 75% of severely asthmatic patients, compared to patients with mild asthma and negative values in control. Conclusion: We report a high percent of A. fumigatus colonization among severely asthmatic patients. This supports the hypothesis of the role of fungal elements colonization in the airways of patients with severe asthma.

DOI

10.21608/mid.2023.199928.1484

Keywords

FUNGAL, sensitization, Asthma

Authors

First Name

Maii

Last Name

Shams Eldeen

MiddleName

A.

Affiliation

Assistant professor of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Egypt.

Email

mai.eldeen@med.tanta.edu.eg

City

-

Orcid

0000-0002-4112-8866

First Name

Reham

Last Name

Elkolaly

MiddleName

M.

Affiliation

Assistant professor of Chest diseases, Faculty of Medicine, Tanta University, Egypt.

Email

reham.elkolaly@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Ragia

Last Name

Sharshar

MiddleName

S.

Affiliation

Assistant professor of Chest diseases, Faculty of Medicine, Tanta University, Egypt.

Email

ragia.sharshar@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Hoda

Last Name

Ibrahim

MiddleName

A.

Affiliation

Lecturer of Medical Biochemistry, Faculty of Medicine, Tanta University. Egypt.

Email

hoda49004@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Mona

Last Name

Watany

MiddleName

M.

Affiliation

Assistant professor of Clinical Pathology, Faculty of Medicine, Tanta University. Egypt.

Email

mona.watany@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Amal

Last Name

Wafi

MiddleName

Abd Elrasheed

Affiliation

Assistant professor of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Egypt.

Email

amal.wafi@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Marwa

Last Name

Abdelwahab

MiddleName

A.

Affiliation

Assistant professor of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Egypt.

Email

marwa.abdelwahab@med.tanta.edu.eg

City

Tanta

Orcid

0000-0003-0298-177

Volume

4

Article Issue

2

Related Issue

40831

Issue Date

2023-05-01

Receive Date

2023-03-14

Publish Date

2023-05-01

Page Start

626

Page End

632

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 2_Pages 626-632.pdf

PDF . 806.9kB

Link

https://mid.journals.ekb.eg/article_293154.html

Detail API

https://mid.journals.ekb.eg/service?article_code=293154

Order

32

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Association between severity of asthma and fungal sensitization in severely asthmatic patients

Details

Type

Article

Created At

25 Dec 2024