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243181

Co-infections and antimicrobial resistance profile of <i>Mycobacterium tuberculosis</i> and <i>Streptococcus pneumoniae</i> among patients with pulmonary infections attending ter

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Medical microbiology

Abstract

Background: Pulmonary infections (Pls) cause mortality in elderly patients that have co-morbidities. These infections are life-threatening in the younger population, especially in infants and children. Co-infection with Mycobacterium tuberculosis and Streptococcus pneumoniae occurring concurrently may lead to undiagnosed Streptococcus pneumoniae leading to inadequate treatment. Aim: The study investigates the co-infection and antimicrobial resistance profile of Mycobacterium tuberculosis and Streptococcus pneumoniae in Makurdi, Nigeria. Materials and methods:  A total of 273 sputum samples were collected from patients with pulmonary infection attending chest clinics in tertiary health institutions in Makurdi and analysed. Genexpert was used for Mycobacterium tuberculosis while Streptococcus pneumoniae isolates were identified using Gram-staining reaction, optochin and bile solubility tests. The susceptibility test for Streptococcus pneumoniae was performed using Kirby-Bauer method. Results: Out of the 273 sputum samples, the percentage occurrence of mono-infections with Mycobacterium tuberculosis was 14(5.13%) while that with rifampicin resistance was 1(0.37%). The occurrence of mono-infection with Streptococcus pneumoniae was 11(4.03%). The resistance profile showed trimethoprim/sulphamethoxazole (septrin) with the highest resistance 6(54.55%) and vancomycin 5(45.45%) while amoxicillin/clavulanic acid and ceftriaxone had zero resistance (0.0%). There was the occurrence of co-infections in 3(1.10%) out of the 273 patients sampled. There was no significant association (p < /em> > 0.05) between Mycobacterium tuberculosis, Streptococcus pneumoniae, their co-infections and the variables analyzed. Conclusion: The occurrence rate of Streptococcus pneumoniae and Mycobacterium tuberculosis co-infections is low among suspected pulmonary infection cases with an occurrence rate of 1.10%. Early detection and proper management of co-infections are recommended.

DOI

10.21608/mid.2022.138402.1314

Keywords

Co-infections, pneumonia, pulmonary, tuberculosis

Authors

First Name

Ageje

Last Name

Isaac

MiddleName

Moses

Affiliation

Department of Microbiology, Faculty of Science, Federal University of Lafia, Nasarawa State, Nigeria

Email

isaacageje@gmail.com

City

Makurdi

Orcid

-

First Name

Joseph

Last Name

Nfongeh

MiddleName

-

Affiliation

Department of Microbiology, Faculty of Science, Federal University of Lafia, Nasarawa State, Nigeria

Email

dejoema@yahoo.com

City

Lafia

Orcid

-

First Name

Yusuf

Last Name

Agabi

MiddleName

-

Affiliation

Department of Microbiology, Faculty of Natural Sciences, University of Jos, Jos, Plateau State, Nigeria

Email

yusufagabi@gmail.com

City

-

Orcid

https://orcid.org/00

First Name

Stella

Last Name

Uneze

MiddleName

Boko

Affiliation

Department of Microbiology, Faculty of Natural Sciences, University of Jos, Jos, Plateau State, Nigeria

Email

elabokolet.sb@gmail.com

City

Jos

Orcid

-

First Name

Paul

Last Name

Abba

MiddleName

Ogor

Affiliation

Benue State Unversity Teaching Hospital Makurdi, Benue State, Nigeria

Email

ogorpaul1969@gmail.com

City

Makurdi

Orcid

-

First Name

Ezekiel

Last Name

Danjuma

MiddleName

-

Affiliation

TB Reference Laboratory, Jos University Teaching Hospital Jos, Nigeria

Email

edanjuma27@gmail.com

City

Jos

Orcid

-

First Name

Kosisochukwu

Last Name

Udeogu

MiddleName

Elijah

Affiliation

Department of Medicine and Surgery, University of Nigeria, Nsukka, Nigeria

Email

udeogukosisochukwu@gmail.com

City

Nsukka

Orcid

-

First Name

Nanma

Last Name

Cosmas

MiddleName

Tongnan

Affiliation

Faculty of Clinical Sciences, College of Health Sciences, University of Jos, Nigeria

Email

nanma@unijos.edu.ng

City

Jos

Orcid

-

First Name

Joseph

Last Name

Anejo-Okopi

MiddleName

Aje

Affiliation

Federal University of Health Sciences, Utukpo, Benue State, Nigeria.

Email

josephokopi@yahoo.com

City

Otukpo

Orcid

-

First Name

John

Last Name

Mawak

MiddleName

-

Affiliation

Department of Microbiology, Faculty of Natural Sciences, University of Jos, Jos, Plateau State, Nigeria

Email

johnmawak@yahoo.co.uk

City

Jos

Orcid

-

Volume

4

Article Issue

2

Related Issue

40831

Issue Date

2023-05-01

Receive Date

2022-05-14

Publish Date

2023-05-01

Page Start

497

Page End

505

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 2_Pages 497-505.pdf

PDF . 996.8kB

Link

https://mid.journals.ekb.eg/article_243181.html

Detail API

https://mid.journals.ekb.eg/service?article_code=243181

Order

19

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Co-infections and antimicrobial resistance profile of <i>Mycobacterium tuberculosis</i> and <i>Streptococcus pneumoniae</i> among patients with pulmonary infections attending ter

Details

Type

Article

Created At

25 Dec 2024