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Comparative cross-sectional study of Interferon Gamma inducible protein-10 in mono and co-infected human Immunodeficiency Virus patients in Alexandria, Egypt

Article

Last updated: 04 Jan 2025

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-

Tags

Medical virology

Abstract

Background: Humanimmunodeficiencyvirus (HIV) infection is a global health issue. Upon invasion, the virus induces many inflammatory cytokines; especially interferon-γ induced protein 10 (IP-10). The aim of our study was to detect and compare the serum IP- 10 levels in HIV mono- infected, hepatitis C virus (HCV) mono- infected patients, and HIV co-infected patients with HCV. Methods: The study included 30 HIV patients (15 mono- infected and 15 co-infected with HCV), 15 HCV infected patients and15 healthy controls. HIV RNA, HCV RNA, CD4+T cell counts, IP-10 levels and Fibrous -4 score were estimated. Results: The mean value for HIV PCR was 1.04*104 ± 3.86*104 in HIV co-infected patients and 4.14*107 ± 1.58*108 in HIV mono-infected patients. The highest mean value for FIB-4 scores and CD4+T cell counts were among HIV co-infected patients; 1.56 ± 2.17 and 432.80 ± 294.83 respectively. HCV mono-infected patients revealed the highest IP-10 mean value; 472.0±235.28.  No significant difference was found in HIV co-infected (p < /em>= 0.806, 0.327) nor HIV mono-infected patients (p < /em>=0.244,0.581) regarding the relation between CD4+T counts 5(> 400 or < 400) with the IP-10 levels and FIB-4 scores respectively. Conclusions: High IP-10 levels were associated with low CD4 cell count in HIV mono and co-infected patients. IP-10 secretion may be related to HIV pathogenesis and immune depletion. HIV/HCV co-infection did not influence HIV disease progression.

DOI

10.21608/mid.2023.189097.1454

Keywords

CD4+T cell, co-infection, Highly active antiretroviral therapy, human immunodeficiency virus, Interferon-γ induced protein- 10

Authors

First Name

Abeer

Last Name

Ghazal

MiddleName

-

Affiliation

Department of Molecular and Diagnostic Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

a_ghazalus@yahoo.com

City

Alexandria

Orcid

-

First Name

Ibtisam

Last Name

EL Ghazawy

MiddleName

-

Affiliation

Department of Molecular and Diagnostic Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

ebtel42@yahoo.com

City

Alexandria

Orcid

-

First Name

Dalia

Last Name

Metwally

MiddleName

El Sayed

Affiliation

Department of Molecular and Diagnostic Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt.

Email

dalia.metwally@alexu.edu.eg

City

Alexandria

Orcid

0000-0002-1810-8218

First Name

Fatma

Last Name

Mohammed

MiddleName

-

Affiliation

Pharmacy Department, Alexandria Hepatology, Gastroenterology and Infectious Disease Hospital, Alexandria, Egypt

Email

fatmath87@gmail.com

City

Alexandria

Orcid

-

First Name

Gihan

Last Name

ELBatouti

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Pharos University in Alexandria, Egypt

Email

g.elbatouti@pua.edu.eg

City

Alexandria

Orcid

0000-0002-5670-5304

Volume

4

Article Issue

2

Related Issue

40831

Issue Date

2023-05-01

Receive Date

2023-01-23

Publish Date

2023-05-01

Page Start

418

Page End

427

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 2_Pages 418-427.pdf

PDF . 585.5kB

Link

https://mid.journals.ekb.eg/article_284812.html

Detail API

https://mid.journals.ekb.eg/service?article_code=284812

Order

11

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Comparative cross-sectional study of Interferon Gamma inducible protein-10 in mono and co-infected human Immunodeficiency Virus patients in Alexandria, Egypt

Details

Type

Article

Created At

25 Dec 2024