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281985

The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients.

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Infectious diseases

Abstract

Background and rationale: Coronavirus disease 2019 (COVID-19) infection is a respiratory tract infection because of a novel coronavirus. The clinical picture ranges from asymptomatic to severe manifestations mandating intensive care and respiratory support. We aimed to assess the serum level of iron, total iron binding capacity (TIBC), and transferrin saturation in COVID-19 patients and their relation to disease severity and outcome. Methodology: This observational cross-sectional analytical study was conducted on 100 confirmed cases of COVID-19 who were admitted to Kasr Al-Ainy hospitals between June and December 2020.Serum levels of iron, total iron binding capacity (TIBC), and transferrin saturation were measured for all study populations. Result: One hundred patients were involved in this research, 51males and 49 females, with a mean age of 51±14.9years. Regarding the disease severity,53% were moderate cases, 34% were mild, and 13% were severe cases. Fifty-two (54.2%) patients showed normal serum levels of iron, 38 patients (39.6%) showed high serum levels of iron, and 6 patients (6.3%) showed low serum levels of iron. The mean ±SD values of iron, TIBC, and transferrin saturation were 163.1±105 mcg/dL, 366 ± 162.6 mcg/dL, 44.4 ± 20.2 %, respectively. Iron, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association as regards either COVID-19 severity or mortality. Mortality and deterioration were detected in 31.7% out of 60 patients with COVID-19. The results showed that obese patients showed a higher percentage of severe COVID-19,which was statistically significant (p < /em>=0.037).There was a statistically significant higher mortality rate in patients with severe COVID-19 (p < /em>=0.000).High mortality was observed significantly in patients with diabetes mellitus (p < /em>=0.041).Iron levels, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association regarding either COVID-19 severity or mortality. Conclusion: In our study, COVID-19 severity was not related to iron metabolism but was affected by obesity and diabetes mellitus. COVID-19 mortality was significantly associated with diabetes.

DOI

10.21608/mid.2023.184087.1439

Keywords

iron, TIBC, COVID-19 patients, disease severity

Authors

First Name

Mira

Last Name

Atef

MiddleName

-

Affiliation

Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

mira.atef@kasralainy.edu.eg

City

-

Orcid

-

First Name

Hala

Last Name

Ramadan

MiddleName

-

Affiliation

Internal Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

halaramadan31@yahoo.com

City

القاهرة

Orcid

0000-0003-3201-5429

First Name

Hanan

Last Name

Abdel-Haleem

MiddleName

-

Affiliation

Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

arady_60@hotmail.com

City

-

Orcid

-

First Name

Rasha

Last Name

Abdalaziz

MiddleName

Ahmed

Affiliation

Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University.

Email

rasha7019@yahoo.com

City

-

Orcid

-

First Name

Aya

Last Name

Al-sharif

MiddleName

Mohamed

Affiliation

Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

ayaelsherif@gmail.com

City

-

Orcid

-

First Name

Reem

Last Name

El-Korashy

MiddleName

Ibrahim Mohamed

Affiliation

Pulmonary Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

reem.elkorashy@kasralainy.edu.eg

City

-

Orcid

-

First Name

Youssef

Last Name

Soliman

MiddleName

Mohamed Amin

Affiliation

Pulmonary Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

ymasoliman@yahoo.com

City

-

Orcid

-

First Name

Sabah

Last Name

Hussein

MiddleName

Ahmed

Affiliation

Pulmonary Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

sabah.hussein@kasralainy.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Hashem

MiddleName

Mohamed

Affiliation

National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.

Email

ahahashem1@gmail.com

City

-

Orcid

-

First Name

Manal

Last Name

Kamal

MiddleName

Mohamed

Affiliation

Clinical and Chemical Pathology department, Faculty of Medicine, Cairo University,Egypt.

Email

manalmk@yahoo.com

City

-

Orcid

-

First Name

Mona

Last Name

Abdullatif

MiddleName

Mohsen Abdulsalam

Affiliation

Clinical and Chemical Pathology department, Faculty of Medicine, Cairo University, Egypt.

Email

mona.abdullatif@kasralainy.edu.eg

City

-

Orcid

-

First Name

Mohammed

Last Name

Abdel Razik

MiddleName

Mostafa

Affiliation

Public health and Community Medicine department, faculty of medicine, Cairo University, Egypt.

Email

mohamed.mustafa@cu.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Ramadan

MiddleName

-

Affiliation

Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University, Egypt.

Email

ahmed.ramadan@kasralainy.edu.eg

City

-

Orcid

-

Volume

4

Article Issue

2

Related Issue

40831

Issue Date

2023-05-01

Receive Date

2022-12-28

Publish Date

2023-05-01

Page Start

393

Page End

400

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 2_Pages 393-400.pdf

PDF . 595.5kB

Link

https://mid.journals.ekb.eg/article_281985.html

Detail API

https://mid.journals.ekb.eg/service?article_code=281985

Order

7

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients.

Details

Type

Article

Created At

25 Dec 2024