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222750

Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpy

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical microbiology

Abstract

Aim and methods: The Schiff base was synthesized by condensation of 2-hydroxy-1-naphthaldehyde with 2-amino-3-methylpyridine and its complexes of Fe (II), Ni (II) and Co (II) chlorides were synthesized and characterized by melting point, solubility test, conductivity, measurement, magnetic susceptibility measurement and  infrared (IR) spectroscopy. The Schiff base and its respective metal complexes were colored with sharp melting point and are soluble in ethanol, dimethylsulfuroxide and methanol but insoluble in water and slightly soluble in other solvent. The conductivity value obtained indicates that the synthesized complexes are non-electrolytes while an octahedral geometry was suggested for all complexes based on the data obtained from magnetic susceptibility analysis. Results: The IR results revealed bands at 1596cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. 791cm-1, 683cm-1, 747cm-1 for (M-N) and 447cm-1, 461cm-1, 451cm-1 for (M-O) bands in the spectra of the complexes supporting coordination of Schiff base to respective metals. Conclusion: The in vitro antimicrobial screening of Schiff base and its metal complexes against  Staphylococcus aureus, Escherichia coli, Streptococcus pneumonia, Klebsiella pneumonia, Aspergillus niger and Candida albicans   showed that they are potential antibacterial and antifungal agents against the tested microorganisms.

DOI

10.21608/mid.2022.118030.1240

Keywords

Key word: synthesis, 2-amino-3-methylpyridine, Antibacterial, Antifungal, Activities

Authors

First Name

Bala

Last Name

Uba

MiddleName

-

Affiliation

Chemistry Department Yobe State University Damaturu Nigeria

Email

balauba85@ysu.edu.ng

City

Yobe State no

Orcid

0000-0002-7380-4953

Volume

4

Article Issue

1

Related Issue

39092

Issue Date

2023-02-01

Receive Date

2022-01-24

Publish Date

2023-02-01

Page Start

312

Page End

322

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 1_Pages 312-322.pdf

PDF . 504.6kB

Link

https://mid.journals.ekb.eg/article_222750.html

Detail API

https://mid.journals.ekb.eg/service?article_code=222750

Order

36

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Antibacterial and antifungal activities of Schiff base and its metal (Ii) complexes of Fe (Ii), Ni (Ii) and Co (Ii) derived from 2-hydroxy-1-naphthaldehyde and 2-amino-3-methylpy

Details

Type

Article

Created At

25 Dec 2024