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270589

The Use of folic acid as a prophylaxis against COVID-19 among healthcare workers

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Infectious diseases

Abstract

Background: Vaccines may be thought of as a reliable intervention to prevent SARS-CoV-2 infection. Prophylactic drugs may be a sound alternative. We aimed to assess the use of folic acid to protect against COVID-19 infection. Methods: This randomized controlled study was conducted in an isolation hospital at Cairo University Hospitals on three groups of nurses caring for COVID-19 patients: group I; the control group, group II whose participants received 500 micrograms of folic acid daily, and group III whose participants received 1000 micrograms daily. PCR conversion was tested for the three groups as a primary endpoint. Results: In total, 526 nurse were included. Group I comprised 139 nurse, group II comprised 163 nurse, and group III comprised 224 nurses. The rates of PCR conversion from negative to positive were 4.9% (8/163) in group II and 1.8% in group III (4/224) compared with 14.4% in the control group I (20/139). Statistically significant (p < /em><0.005) and highly statistically significant (p < /em><0.001) differences respectively were found. Conclusions: Prescribing folic acid daily may significantly decrease the risk of COVID-19 infection among exposed healthcare workers.

DOI

10.21608/mid.2022.170328.1405

Keywords

COVID-19, Folic acid, Prophylaxis, Healthcare workers

Authors

First Name

Ahmed

Last Name

Farag

MiddleName

-

Affiliation

General Surgery Department, Faculty of Medicine, Cairo University

Email

ahmed.farag@kasralainy.edu.eg

City

-

Orcid

-

First Name

Nadia

Last Name

Ouda

MiddleName

Hafez

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University

Email

nadiahafez@gmail.com

City

-

Orcid

-

First Name

Reham

Last Name

Dwedar

MiddleName

A

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University

Email

rehamdwedar@gmail.com

City

-

Orcid

-

First Name

Dalia

Last Name

Bilal

MiddleName

-

Affiliation

Department of Cancer Epidemiology and Biostatistics, National Cancer Institute, Cairo University

Email

daliabilal123@gmail.com

City

-

Orcid

-

First Name

Aml

Last Name

Said

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University

Email

aml.said@kasralainy.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Elbarmelgi

MiddleName

Yehia

Affiliation

General Surgery Department, Faculty of Medicine, Cairo University

Email

dr.yeho@cu.edu.eg

City

-

Orcid

-

First Name

Ahmad

Last Name

Al Shafie

MiddleName

-

Affiliation

Department of Endemic Medicine, Faculty of Medicine, Helwan University

Email

al.shafie29@gmail.com

City

-

Orcid

-

First Name

Hala

Last Name

Talaat

MiddleName

S.

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Yasmine

Last Name

Elkholy

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University

Email

yasminelkholy@kasralainy.edu.eg

City

Cairo

Orcid

0000-0002-0654-3415

Volume

4

Article Issue

1

Related Issue

39092

Issue Date

2023-02-01

Receive Date

2022-10-23

Publish Date

2023-02-01

Page Start

56

Page End

62

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 1_Pages 56-62.pdf

PDF . 382.9kB

Link

https://mid.journals.ekb.eg/article_270589.html

Detail API

https://mid.journals.ekb.eg/service?article_code=270589

Order

9

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

The Use of folic acid as a prophylaxis against COVID-19 among healthcare workers

Details

Type

Article

Created At

25 Dec 2024