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267362

Interleukin-17: Could it be a key player in COVID-19 infection severity?

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Medical microbiology

Abstract

Background: Exaggerated cytokines response with release of proinflammatory cytokines i.e., cytokine storm has been described with COVID-19 infection. This cytokine storm plays an important role in lung injury and development of acute respiratory distress syndrome (ARDS) in severely ill patients. One important cytokine that participates in the cytokine storm is interleukin (IL) -17. Aim of the study: Assess serum levels of IL-17 in COVID-19 patients and its correlation with disease severity. Methods:  Sixty-six COVID-19 infected patients (33 moderate cases and 33 severe cases) and 20 healthy controls (HCs) were included in the study. Serum IL-17 level was assessed by ELISA in patients and HCs. Results: IL-17 levels were remarkably higher in patients' groups compared to HCs and also there was statistically significant difference between the patients' subgroups (p < /em><0.0001). IL-17 was correlated with different laboratory and clinical parameters. At a cut-off value of >25 ng/ml, IL-17 was able to differentiate between the patients' groups and HCs with 93.94% sensitivity and 65% specificity. Conclusion: Serum IL-17 level correlates to more severe disease courses in COVID 19 patients. Higher levels were associated with devastating outcomes.

DOI

10.21608/mid.2022.166373.1390

Keywords

Interleukin-17, COVID-19, Cytokines, disease severity, ICU

Authors

First Name

fatma el zahraa

Last Name

fathy

MiddleName

Y.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University

Email

drfatmayoussef@med.asu.edu.eg

City

cairo

Orcid

0000000267877734

First Name

Nadia

Last Name

Elsheshtawy

MiddleName

M.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University

Email

nadiamohamed@med.asu.edu.eg

City

-

Orcid

0000-0001-8337-526X

First Name

Mayada

Last Name

Moneer

MiddleName

-

Affiliation

Department of internal medicine, Faculty of Medicine, Ain Shams University

Email

mayada_moneer@med.asu.edu.eg

City

-

Orcid

0000-0002-6700-9662

First Name

Amr

Last Name

hosny

MiddleName

-

Affiliation

Department of Anaesthesia and Intensive care , Faculty of Medicine, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Marwa

Last Name

Abd Elgawad

MiddleName

Abd Elazeem

Affiliation

Geriatrics medicine and gerontology department , Faculty of Medicine, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Amira

Last Name

Abdelhamid

MiddleName

E.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University

Email

amira.esmail2016@yahoo.com

City

-

Orcid

-

Volume

4

Article Issue

1

Related Issue

39092

Issue Date

2023-02-01

Receive Date

2022-10-01

Publish Date

2023-02-01

Page Start

36

Page End

43

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 1_Pages 36-43.pdf

PDF . 499.3kB

Link

https://mid.journals.ekb.eg/article_267362.html

Detail API

https://mid.journals.ekb.eg/service?article_code=267362

Order

7

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Interleukin-17: Could it be a key player in COVID-19 infection severity?

Details

Type

Article

Created At

25 Dec 2024