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279298

Secondary multidrug resistant bacterial pneumonia among adult COVID-19 patients: A molecular study

Article

Last updated: 04 Jan 2025

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-

Tags

Clinical microbiology

Abstract

Background: Secondary bacterial pneumonia especially with multidrug resistant (MDR) organisms is one of the devastating complications that can worsen COVID-19 patients' outcomes.The study aimed to evaluate the impact of secondary MDR bacterial pneumonia on COVID-19 patients' outcomes with molecular detection of genes involved in antimicrobial resistance among isolates of the most prevalent causative pathogen. Methods: Thestudy included 50 critically ill patients with acute severe COVID-19 with evidence of secondary MDR bacterial pneumonia, 50 critically ill patients with acute severe COVID-19 without evidence of secondary bacterial pneumonia, and 30 clinically stable patients with acute moderate COVID-19 infections. Respiratory samples were cultured for identification and antibiotic susceptibility of the causative pathogens. MDR/XDR A. baumannii, the most prevalent pathogen, was screened for multiple antibiotic resistance genes using single-plex and multiplex polymerase chain reactions. Results: Critically ill COVID-19 patients with secondary MDR bacterial pneumonia in group I had a significantly higher mortality rate.MDR/XDR A. baumannii was the most prevalent pathogen (39.2%) isolated with the highest cause specific mortality rate (38%). Multiple resistance genes were detected including 𝑏𝑙𝑎OXA-51, 𝑏𝑙𝑎OXA-48, 𝑏𝑙𝑎OXA-24, 𝑏𝑙𝑎ADC,𝑏𝑙𝑎CIT, 𝑏𝑙𝑎KPC, aacA4, aacC1, acc (6'), aphA1, aph6, and aadA1. Conclusion: Secondary MDR bacterial pneumonia had a significant impact on critically ill COVID-19 patients with a significantly higher mortality rate. Thus, preventing secondary MDR bacterial pneumonia through infection prevention measures, including standard precautions, preventive care bundles and antimicrobial stewardship programs, should be strictly implemented to protect critically ill COVID-19 patients and help avoid its detrimental effect on patients' outcomes.

DOI

10.21608/mid.2023.181978.1427

Keywords

SARS-CoV-2, COVID-19, Antimicrobial, resistance, Acinetobacter

Authors

First Name

Reham

Last Name

Khalifa

MiddleName

-

Affiliation

Medical Microbiology and Immunology department, Faculty of Medicine, Ain Shams University.

Email

drreham_khalifa@med.asu.edu.eg

City

Cairo

Orcid

0000-0003-3012-1164

First Name

Bothayna

Last Name

Ismail

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt.

Email

salehb08@gmail.com

City

-

Orcid

-

First Name

Hani

Last Name

Al-Jahdali

MiddleName

-

Affiliation

Medical Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Email

haljahdali@moh.gov.sa

City

Jeddah

Orcid

-

First Name

Huda

Last Name

Alghamdi

MiddleName

-

Affiliation

Laboratory Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Email

hudaalghamdi04@hotmail.com

City

Jeddah

Orcid

-

First Name

Husam

Last Name

Joharjy

MiddleName

-

Affiliation

Infection Control Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Email

hjoharjy@moh.gov.sa

City

Jeddah

Orcid

-

First Name

Khalid

Last Name

Eibani

MiddleName

-

Affiliation

Surgery Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Email

keibani@moh.gov.sa

City

Jeddah

Orcid

-

First Name

Randa

Last Name

Sabour

MiddleName

-

Affiliation

Radiology department, Faculty of Medicine, Al Azhar University, Cairo, Egypt.

Email

randa_sabour@yahoo.com

City

Cairo

Orcid

-

First Name

Fahd

Last Name

Almalki

MiddleName

-

Affiliation

Medical Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Email

fhdmaalki@gmail.com

City

Jeddah

Orcid

-

First Name

Saleh

Last Name

Alfarhan

MiddleName

-

Affiliation

Medical Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Email

dr.saleh.alfarhan@gmail.com

City

Jeddah

Orcid

-

First Name

Mohammed

Last Name

Alatram

MiddleName

-

Affiliation

Medical Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Email

dr.m.alatram@gmail.com

City

Jeddah

Orcid

-

First Name

Mohammed

Last Name

Algozi

MiddleName

-

Affiliation

Medical Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Email

moh_abdu@hotmail.com

City

Jeddah

Orcid

-

First Name

Abdulilah

Last Name

Aljehani

MiddleName

-

Affiliation

Medical Department, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Email

abdu_lilah_2007@hotmail.com

City

Jeddah

Orcid

-

First Name

Ali

Last Name

Alasmari

MiddleName

-

Affiliation

Jeddah Regional Laboratory, Jeddah, Saudi Arabia

Email

fructose2011@gmail.com

City

Jeddah

Orcid

-

Volume

4

Article Issue

1

Related Issue

39092

Issue Date

2023-02-01

Receive Date

2022-12-20

Publish Date

2023-02-01

Page Start

11

Page End

26

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 4_Issue 1_Pages 11-26.pdf

PDF . 910.5kB

Link

https://mid.journals.ekb.eg/article_279298.html

Detail API

https://mid.journals.ekb.eg/service?article_code=279298

Order

5

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Secondary multidrug resistant bacterial pneumonia among adult COVID-19 patients: A molecular study

Details

Type

Article

Created At

25 Dec 2024