Introduction: Several lines of evidence support the link between moderate Combination of Resistance & Aerobic Training (CRAT) and improved immunity leading to lowered infection rates. Moderate exercise training (aerobic training) causes favorable perturbations in immunity and a reduction in incidence of illness. During each bout of moderate exercise, an enhanced recirculation of mononuclear cell {CD3, CD4, CD8, CD14, CD19& CD56} in Women occurs that persists for up to 3 hours post-exercise. Rush of immune cells from the innate immune system which activated by exercising are temporary but boosts overall surveillance against pathogens. Practicing regular moderate exercise for three months can be effect on body weight decreasing and period of illness symptoms caused by obesity. Study aim: To assess the Effects of Combination of Resistance & Aerobic Training (CRAT) on Changing of Mononuclear cell {CD3, CD4, CD8, CD14, CD19& CD56} & Body composition in Women. Material and methods: one Experimental group of Women were engaged in this study, (15 women m.67.7± 2.7 yr.; range 65- 73). Obese women were engaged in training (CRAT) controlled in the same training session for trained 4-month, three times a week, 90 min per session, on non-consecutive days and exercised under the supervision of a personal trainer, to determine changes on Mononuclear cell {CD3, CD4, CD8, CD14, CD19& CD56}. Blood samples were obtained from all subjects {CRAT} pre at rest, post immediately after resistance exercise, before (week 0) and after week 16 after training. Results: This study showed that Combination of Resistance & Aerobic Training (CRAT) increased Mononuclear cell {CD3, CD4, CD8, CD14, CD19 & CD56} and decreased body composition P<0.01). Conclusions: Increased components of mononuclear cell and decreased body composition after Combination of Resistance& Aerobic Training (CRAT) suggest that immunity has been improved.