Natural gas is the most significant and common fossil fuel in the present time. it may contain several non- hydrocarbon components such as, hydrogen sulphide and carbon dioxide. Gulf of Suez Gas Plant (GOS) operated by Gulf of Suez Petroleum Company (GUPCO) in Egypt. This plant used Di Ethanol Amine (DEA) for sweetening process, and it has received a huge amount of acid gas over than the design conditions 300 Part Per Million (PPM), which lead to corrosion issue. And recommended to study and simulate another type of amine chemicals ,that can be used for sweetening to meet concentrations of H2S in sweet gas was about 4 Part Per Million (PPM)[1-3]. This study aims to simulate Gulf of Suez Gas Plant (GOS) gas sweetening process by using aspen hysy V,12 program and focuses on using amine solutions for example; Mono Ethanol Amine (MEA) and Piperazine (PZ) . The novel process can be reduced chemical consumption by doing preparatory calculations.The impacts of feed flow rate, feed pressure, acid gas content (CO2 and H2S) in feed, and the cost of chemical based on mass flow rate were investigated. In certain ranges of feed flow rates, pressures, and acid gas concentrations. The Mono Ethanol Amine (MEA) process is less expensive than an independent Piperazine (PZ) process. And it is expected to provide low-cost technology for capturing H2S and CO2 from wet natural gas.The optimization found that the use of Mono Ethanol Amine (MEA) (32 weight% ) may be considered the most recommended process.