Background: Coronavirus disease 2019 (COVID-19) pandemic impacted both healthcare services quality & patient satisfaction. Patient satisfaction is a measure of the quality of healthcare services. Because of restrictions on global movement, the COVID pandemic precipitated unpredictability & a scarcity of medical supplies. Aim of the study: to evaluate patient satisfaction during COVID pandemic & related factors at National Liver Institute hospital (NLI), Menoufia University, Egypt. Methods: Six months cross sectional hospital-based research performed during COVID-19 Pandemic from 1^st April to 30^th September 2022 on 415 randomly selected patients either admitted or followed-up at NLI hospital. For collecting information, a structured interviewer-administered questionnaire was utilized. Results: The overall patient satisfaction score was 97.1%. Among the sociodemographic factors measuring the total satisfaction level of our studied patients; Patient's age, address & occupation were significantly related with overall patient satisfaction score with 0.021, 0.007 & 0.036 p values respectively. While among the hospitalization factors; Time passed since first visit, the frequency of visiting NLI hospital and hospital department type were significantly related with overall patient satisfaction score with 0.006, 0.01 & 0.02 p values respectively. 82.2 % patients' satisfaction regarding COVID-19 NLI hospital prevention and control measures. Conclusion: Appropriate precautions taken by NLI healthcare workers to address patients' safety during COVID-19 pandemic increases overall patients' satisfaction score. Keywords: Patient satisfaction; COVID-19; Associated factors.