Background; Neurodevelopment deficits have long been recognized as a major complication of pediatric chronic kidney disease (CKD). Some of this impairment has been attributed to the possible effects of kidney failure: uremia, anemia, hypertension and malnutrition,However, no published papers specifically examining the prevalence of ASD within the pediatric nephrology population.
 
Aim and objectives; this study designed to evaluate the association of autistic spectrum disorder with pediatric chronic kidney diseases.
 
Subjects and methods; This is an Observational Cross Sectional study that included One hundred children with chronic kidney disease not on dialysis recruited from the Pediatric nephrology Clinic, Pediatrics Department , Faculty of Medicine, Ain Shams University, Cairo, Egypt, during their follow up visits from February 2022 to august 2022 , randomly selected, all selected patient were subjected to detailed history ,full clinical  examination and pediatric symptoms check list questionnaire. 
 
Result; no autistic disorders were detected in our studied group but behaviour change was demonstrated in 9 percent of studied group < /p>
 
Conclusion; no correlation between chronic kidney diseases and autism but there is a positive correlation between CKD and behavioral problems .