Background: The association between elevated levels of Vitamin B12 and folic acid and the occurrence of epileptic seizures in humans is a subject of ongoing debate. The aim of this study to evaluates the influence of blood concentrations of Vitamin B12 and folic acid on children diagnosed with idiopathic epilepsy.
Method: Our study was carried out on a sample of 44 youngsters diagnosed with idiopathic epilepsy, along with 11 individuals who were selected as healthy controls. The participants were recruited from Bab El Sharia University Hospital. The research was carried out from November 2022 to July 2023. All the studied were subject to comprehensive medical history, thorough physical examination, and assessing the concentrations vitamin B12 and folic acid. Then the patients' groups were supplemented with vitamin B12 (100mcg/24hour for 14 days then once weekly for 3 months) and folic acid (50mcg/day for 3 months) from November 2022 to July 2023. Lastly. Evaluation of patients' clinical condition and the measurement of vitamin B12 and folic acid levels were done.
Results: our study indicates that folic acid and vitamin B12 had favorable results in terms of the clinical neurological status of individuals diagnosed with idiopathic epilepsy. In comparison to the baseline measurements, the administration of vitamin B12 and folic acid supplements resulted in a substantial decrease in both the frequency of seizures per month and the severity score of seizures.
Conclusion: Folic acid and vitamin B12 have a positive impact on the neurological results seen in individuals with idiopathic epilepsy. The administration of Vitamin B12 and folic acid resulted in a significant decrease in monthly occurrence of seizures and the severity of seizures in individuals with idiopathic epilepsy.