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325922

DETECTION AND POTENTIAL UTITITY OF SALIVARY C-REACTIVE PROTEIN FOR DIAGNOSIS OF NEONATAL SEPSIS

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Last updated: 25 Dec 2024

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Abstract

Objective: To evaluate salivary CRP as a diagnostic and prognostic biomarker in neonatal sepsis.
Subjects and Methods: This case-control study included 64 neonates were selected from Ain Sham University Hospital during the period from May 2022 and March 2023 by simple random method, assigned to two equal groups; septic group and a control group. Clinical findings and routine laboratory data including blood culture and complete blood picture results were documented. According to hospital protocol, Serum CRP was measured while salivary CRP levels were measured using enzyme-linked immunosorbent assay.
Results: The median salivary CRP was significantly higher in septic neonates compared to controls (p < 0.001). For salivary CRP, the optimum cut-off value for sepsis diagnosis was found to be 1.27 mg/L with sensitivity, specificity, positive and negative predictive values of 96.9%, 96.9%, 96.9%, and 100%, respectively. strong positive correlation was found between the levels of salivary and serum CRP (r =.962, p = 0.001).
Conclusion: Salivary CRP, at a cut-off value of 1.27 mg/L, exhibited a high specificity and positive predictive value in sepsis diagnosis and showed positive correlation with serum CRP.
 
 

DOI

10.21608/azjp.2023.325922

Keywords

Key words: Neonatal sepsis, salivary CRP, serum CRP

Volume

26

Article Issue

4

Related Issue

44356

Issue Date

2023-10-01

Receive Date

2023-11-13

Publish Date

2023-10-01

Page Start

3,615

Page End

3,629

Print ISSN

1110-7774

Online ISSN

3009-7770

Article File

AZJP_Volume 26_Issue 4_Pages 3615-3629.pdf

PDF . 219.7kB

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https://azjp.journals.ekb.eg/article_325922.html

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https://azjp.journals.ekb.eg/service?article_code=325922

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3

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Original Article

Type Code

1,135

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pediatrics

Publication Link

https://azjp.journals.ekb.eg/

MainTitle

DETECTION AND POTENTIAL UTITITY OF SALIVARY C-REACTIVE PROTEIN FOR DIAGNOSIS OF NEONATAL SEPSIS

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Type

Article

Created At

25 Dec 2024