This study was conducted to evaluate nine insecticidal combinations against the whitefly Bemisia tabaci (Gennadius) and the Leafminer Liriomyza sativae (Blanchard) attacking cucumber crops in the open field during 2022 and 2023 seasons. These treatments were abamectin, abamectin with bifenthrin, chlorfenapyr, fenpropathrin with etoxazole, jojoba oil, imidacloprid, imidacloprid with abamectin, thiamethoxam and thiamethoxam with abamectin. All treatments resulted in significant reduction on both insects. Chlorfenapyr was the most effective compound against whitefly at initial effect, 5, 7, 10 days after treatments and overall average by 95.3±0.32, 94.95±0.00, 92.50± 0.23, 89.99±0.66 and 93.19%, In the first season and 94.18±0.90 ,95.83±0.00, 93.41±0.29, 87.49±0.26, and 92.73 % in the second season. Fenpropathrin with etoxazole was the most effective compound against Leafminer by 97.91±1.06, 93.06±0.24 ,84.97±0.06, 94.34±0.75 and 92.57% in the first season and 95.51±0.70, 93.11±0.20, 91.48±0.26 ,92.33±0.75 and overall average 93.11%in the second season. All compounds significantly increased chlorophyll content at initial, five and seven days. However, chlorophyll content was almost normal except with using imidacloprid that reduced chlorophyll. Almost all treatments reduced significantly the antioxidant enzymes and non-enzymatic components in cucumber plants.