Recently, there has been interest in substituting ordinary mineral equivalents with nanoparticles (NPs), notably those derived from micronutrients. This experiment was carried out during two progressive seasons of 2021 and 2022 on 45 years-old Manfalouty and Hejazy pomegranate cultivars grown in the research orchard and laboratories of Pomology department, faculty of agriculture, Assiut university, Egypt. The aim of this study was to evaluate the effect of Nano & conventional Zinc oxide and their comparative efficacy on fruit quality and marketable yield. Zinc Oxide conventional and nanoparticle (ZnO NPs) with two concentrations of each other (15 and 25 ppm), two sources of Zinc Oxide were sprayed twice (first: at full bloom and the second after a month from the first one). Results showed that Nano Zinc at 15 and 25 ppm led to a significant improvement in almost studied characters (leaf area, fruit, arils and rind weight, juice volume, TSS, TSS/ acid, reducing sugars and total acidity percentage in fruit juice).