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397260

VERIFYING THERAPEUTIC POTENCY OF SHILAJIT AGAINST CRYPTOSPORIDIOSIS: AN EXPERIMENTAL STUDY

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Last updated: 25 Dec 2024

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Abstract

In immunocompromised hosts, diarrheal disease is primarily caused by Cryptosporidium spp. 
infect-ion. Up- to-date, there is neither vaccine nor safe or efficient treatment. Shilajit is one the 
medicinal plants. This study evaluated Shilajit anti-cryptosporidiosis alone or with Nitazoxanide® 
(NTZ) in immunocompromised Albino mice. The study comprised fifty mice divided into five gr
oups of ten mice each.  The oocysts shedding were assessed parasitologically by stained fecal 
smears, histologically in liver and small intestine, and immunologically by evaluation of IFN-γ 
and IL-10 levels. 
The results showed that shilajit improved the liver and small intestine significantly by oocysts 
reduction in feces and small intestine. Mice treated with both shilajit and NTZ showed the best 
improvement. IFN-γ increased and IL-10 decreased (P< 0.001) in all treated mice. 

DOI

10.21608/jesp.2024.397260

Keywords

Cryptosporidium parvum, shilajit, Nitazoxanide, Immunocompromised mice

Authors

First Name

SHAIMAA

Last Name

MOHAMED

MiddleName

S.

Affiliation

Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

HODA

Last Name

SABRY

MiddleName

Y.

Affiliation

Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

NEIMAT

Last Name

AMER

MiddleName

M.

Affiliation

Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

SOHEIR

Last Name

MAHMOUD

MiddleName

S.

Affiliation

Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

WAFAA

Last Name

EL KOMI

MiddleName

-

Affiliation

Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

EMAN

Last Name

SELIM

MiddleName

H.

Affiliation

Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

TAREK

Last Name

ABOUSHOUSHA

MiddleName

-

Affiliation

Department of Pathology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

SHIMAA

Last Name

ATTA

MiddleName

A.

Affiliation

Department of Immu nology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

FATMA EL-ZAHRAA

Last Name

SALEH

MiddleName

R.

Affiliation

Department of Water Pollution Research, Environmental and Climate Change Institute, National Research Centre (NRC), Egypt

Email

-

City

-

Orcid

-

First Name

EMAN

Last Name

EL-WAKIL

MiddleName

S.

Affiliation

Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt

Email

-

City

-

Orcid

-

Volume

54

Article Issue

3

Related Issue

52146

Issue Date

2024-12-01

Receive Date

2024-12-16

Publish Date

2024-12-01

Page Start

447

Page End

452

Print ISSN

1110-0583

Online ISSN

2090-2549

Article File

JESP_Volume 54_Issue 3_Pages 447-452.pdf

PDF . 3.8MB

Link

https://jesp.journals.ekb.eg/article_397260.html

Detail API

https://jesp.journals.ekb.eg/service?article_code=397260

Order

13

Type

Original Article

Type Code

1,127

Publication Type

Journal

Publication Title

Journal of the Egyptian Society of Parasitology

Publication Link

https://jesp.journals.ekb.eg/

MainTitle

VERIFYING THERAPEUTIC POTENCY OF SHILAJIT AGAINST CRYPTOSPORIDIOSIS: AN EXPERIMENTAL STUDY

Details

Type

Article

Created At

25 Dec 2024