Generally, the common etiology of gastritis infection with Helicobacter pylori (H. pylori) is increasing.
Vonoprazan inhibits the activity of H+/K+ ATPases, with greater effect than PPIs on
decreasing gastric acidity. This randomized controlled study was performed on two Egyptian patients
groups: G1: 160 patients treated with Vonoprazan, Levofloxacin and Amoxicillin for two weeks, and
G2: 160 pat-ients treated with Pantoprazole, Levofloxacin andAmoxicillin for two weeks. Testing
fecal H. pylori Ag for all patients was done 8 weeks later after the completion of treatment course.
The results showed that 136 of 160(85%) patients were negative for H. pylori Ag in G1 compared to
112/160(70%) patients in G2 with the In intention to treat (ITT) analysis and per-protocol (PP)
analysis, for eradication rates was in G1greater than in G2 (P = 0.004, 0.002), respectively.