A total of 15 goats were randomly divided into five groups (n =3): control (no treatment), deltamethrin
(5mg/kg), fipronil (10mg/kg), ivermectin (0.2mg/kg), and deltamethrin & fipronil. Fleas
were counted at 0-, 2-, and 6-weeks post-treatment Blood samples were collected at the same time
points of (deltamethrin & fipronil) to determine hemato-biochemical parameters such as Red blood
cells (RBC), White blood cells (WBC), Hemoglobin (Hb), Hematocrit (Hct), Alanine aminotransferase
(ALT), Aspartate aminotransferase (AST), Total protein (TP), Albumin (Alb), Globulin
(Glo), Cholesterol (Chol), Creatinine (Cr), Urea (Urea), and Glucose (Glu). Physiological performance
was assessed by rectal temperature, skin temperature, respiration rate and pulse rate. The
results showed that combination therapy had the highest efficacy against flea infestation compared
to ivermectin treatment or the control group. The combination therapy also improved hematobiochemical
parameters such as RBC, HGB, HCT, and T3 compared to the control group or ivermectin
treatment. The combined therapy significantly decreased ALT, AST or Cortisol compared
to the control group or single treatments.