Trichinellosis (= trichinosis) is widespread food-borne zoonotic parasitosis caused by the nematode
Trichinella spiralis triggering skeletal muscle injury. This study identified the therapeutic
effects of platelet-rich plasma (PRP) as a safe choice in muscular phase of mice experimental infected
with T. spiralis. Ninety male mice were divided into three main groups, GI: Negative control,
GII: Positive control and GIII: Trichinella infected PRP treated. All mice were sacrificed on
14th day post infection (initiation of muscle cell invasion), on 21st day (early stage of nurse cell
formation), on 28th day (formation of most nurse cells was completed), and on 35th day PI (convalescent
period). The parasitological examination showed a significant reduction in the number
of larvae detected in the infected PRP-treated ones 35th PI. Histopathological and immunohistochemical
of vascular endothelial growth factor, caspase 3 analyses coincided with parasitological
findings, on 35th day PI as well. There was a significant improvement in the in-flammatory
cells with fewer muscle fibers degradation, indicating that PRP injection in trichinellosis muscular
phase improved inflammatory reaction and reduce T. spiralis larval burden.