The repeated exposure of the immune system to bee venom as antigen leads to significant increase
in immune response. In this study different immunological schedules were tried to reach
maximum immunological effect with the least allergic side effect either by using and aqueous or
emulsified preparation of bee venom. Three groups of male rabbits of one year old each were
used for a period of four weeks. The blood samples were with drown before bee venom injection
and weekly after its infection for determination of IgG and IgE. The results showed that injection
of Egyptian bee venom in an aqueous form have the ability to boost the level of immune response
without significant allergic reaction.