Trichinellosis is a resurgent parasite that affects people globally. Acid suppressing drugs (ASDs) are among the most frequently prescribed and generally safe medications in many distinct processes (changes defense mechanisms as gut microbiota and immunology). The study evaluated the antacids effect of aluminium hydroxide and magnesium hydroxide in treating Trichinella spiralis in experimental infected mice. Mice (128) were divided into four groups GI: negative control (non-infected untreated), GII: positive control (infected un-treated), GIII: mice were infected and treated with albendazole and GIV: mice were infected and treated with antacids. Half of them were sacrificed on 7th day post infection (PI) for in-testinal phase and second half were sacrificed on 35th day PI for muscular phase. Treatment efficiency was assessed by parasitological, biochemical and histopathological examinations. The results showed that antacids treated mice gave highest number of T. spiralis adult count in intestine and larval count in muscle. Antacids increased the infection (30.5%, 32.5%) respectively compared to infected control. Biochemically showed higher level of IL4, IL10, MDA and lower level of GSH than infected control