Background: To reduce the duration of orthodontic therapy, it has become necessary to accelerate orthodontic tooth movement. This reduces the risks that could arise throughout the extended course of treatment. Orthodontic friction is defined as the engagement of the archwire with bracket slot and the ligation. Thus, one of the primary objectives of biological orthodontic tooth movement is to reduce friction. One technique to reduce frictional resistance is orthodontic archwire coating, which modifies archwire surface characteristics. Several tactics have been devised for wire coatings. However, nanotechnology is one of the technologies that was introduced in the field of orthodontics. The aim of the study aimed to determine whether zirconium dioxide nanoparticles coated orthodontic appliances demonstrate less friction in vitro than non-coated orthodontic appliances. Material & method: The study was performed on 60 sample. The specimens were randomly divided into four groups. G1: is the control group using conventional archwires with convention uncoated brackets; G2: both the archwires and brackets are coated; G3: coated archwire only with uncoated bracket; and G 4: coated brackets only with conventional archwire. Each group was tested under dry and wet conditions. The resistance to sliding was measured using a universal testing machine. Results: There was a statistically significant difference between G1 and G2, G3, and G4 in terms of frictional resistance under both wet and dry conditions. With high friction in G1 and the lowest friction in G3 and G4. There was no significant difference between the dry and wet conditions in the same group.