This study emphasizes the great impacts of the process of injection gold nanoparticles (AuNPs) through the blood vessels of the human body for cancer therapy. This investigation handles the effects of the heating process, the slipping, the gravity, and the various shapes of the nanosize particles on the behavior of the blood flow in a tube. The kinetics of gold-blood flow of nanofluid occurs according to the peristaltic wave which motives the flow through the body. The efficient Hamilton-Crosser model for the nanofluid thermal conductivity is selected. The governing equations of the incompressible non-Newtonian nanofluid are solved under the procedures of the perturbation strategy with a small wavenumber and long wavelength. Graphical results for the velocity, the temperature distributions, and the streamlines are deduced using MATLAB software under the effect of the heat source, Grashof number, Shapes of the AuNPs (Bricks, cylinders, and platelets), AuNPs concentrations, and slipping conditions. The results show a great impact of the heat transfer, shape factor, and the concentration of the injected AuNPs on the cancer treatment.