Concrete filled tubular steel CFST members are recently used widely due to their proved efficiency. CFST members can carry high axial compression forces which merge the advantages of steel and concrete sections. This paper presents an investigation for the use of CFST members as compression elements in space frames through experimental and finite element (FE) modeling program. This program included two steps. The first step presents a comparison between hollow steel and CFST slender columns. The second step considers the behavior of full space truss with CFST members. The study also presents a finite element modeling for all tested specimens (steel and CFST members). Test results like ultimate load capacity, load against axial shortening and deformed mode shape are presented and discussed. The study reported the improvements that obtained by applying the technique of replacing the compression members in space trusses with CFST elements. The finite element showed an excellent agreement with experimental results.