Abstract
Background: Inhalation injury-based respiratory failure is
the main cause of death in patients with severe burns. In general,
damage from smoke inhalation results in airway edema,
inflammation and, subsequently, cellular debris, mucus, fibrin
clots and polymorphonuclear leukocytes PNL combine to form
casts that lead to ventilation/perfusion mismatch and poor oxygenation.
Objective: This meta-analysis aims to review the Guideline
of Management of Acute Smoke Inhalation Injury and discuss
the different modalities and treatment.
Material and Methods: A comprehensive search of the
literature to identify the Guideline of Management of Acute
Smoke Inhalation Injury and discuss the different modalities
and treatment. via electronic databases including OVID, Science
Direct, Springer, Web of Science and Google Scholar. Initial
search will carried out using keywords: “burns, “ARDS,"
“adult respiratory distress syndrome", “extracorporeal membrane
oxygenation", “ECMO," “inhalation injury", "smoke
inhalation injury", and “heparinized oxygen mask", "ECMO".
Results: All published articles were from 2013 to 2022
limited to human studies of different modalities will be analyzed
and compared regarding the criteria of management.
Conclusion: The care of patients with burn related inhalation
injury remains highly challenging. Key topics include
airway management, nebulized heparin, NAC, chest physiotherapy
and ECMO effect.
Early ambulation, nebulized Heparin in combination with
NAC and albuterol was associated with a reduction in the duration
of mechanical and decrease mortality rate.
Key Words: Acute Smoke Inhalation Injury – Burn Injuries
– Nebulized Heparin – Chest Physiotherapy –
ECMO Effect.