Osteoporosis is a particularly prevalent ailment among menopausal women. Since bone mineral density (BMD) declines with age, primary osteoporosis primarily affects women 10-15 years after menopause.  Once, the research's goal was to investigate how flax seed and sesame powder affected osteoporosis in rats. In this study, 35 female albino rats that weigh 150±5 g were split up into six groups of five rats each. The first was kept as a control -ve group, while the other five were given prednisone at a rate of 4.5 mg per kg (over the course of two weeks) to induce osteoporosis. The second group of rats served as the positive control group. Other treated groups fed on 2.5 and 5% sesame, flax seeds, and their mixtures. When the experiment finished, the rats had been fasting for the previous day. before being sacrificed, and blood was gathered and then centrifuged to separate the serum. Lipid profile including cholesterol, triglycerides, HDL, LDL and VLDL, kidney functions, and do a dexa scan of the appropriate femur taken; BMD and BMC of measure the BMD and BMC of every bone; and use part of the bone to estimate the amount of calcium and phosphorus in the body. The data collected demonstrated that treated groups with 5%mixtures of flax seed and sesame led to a significant decrease in all lipid cholesterol and renal biomarkers, and vice versa with HDL-c, BMD, BMC, calcium, and phosphorus.