Aflatoxins (AFs) are deleterious components that bring about cancerogenic effects on tissues. It can produce oxidative stress provocation cells into evil. However, bioactive compounds from natural plant species might prevent toxic substances produced by a fungus, from causing sick effects. Radish white roots (RWRs), a source of active substances, have favorable indispensable effects and are the most known consuming part and utilized as vegetables by multiple communities. Total flavonoids and phenolics compounds and the total antioxidant capacity were identified in WRRs. The experiment was designed by using five rat groups to evaluate the potential WRRs effect to reduce the deleterious oxidative stress effects of AFs. The negative rat group was orally given distilled water and kept as a normal group. Treated groups were orally given aflatoxins (AFB₁) without RWRs (Positive group) and with RWRs in diets (treated groups). Diet fortification by 10, 15, and 20% of RWRs of AFB₁-treated rats exhibited an augmentation in body weight, and food efficiency ratio, as well as improvements in liver enzymes, kidney function, and serum lipids, in comparison to AFs treated-group only. In addition, the reduction in serum levels of albumin, total protein, globulin, and activities of antioxidant enzymes by AFs were ameliorated by RWRs attendance in diets. Histopathological inspection of the liver from AFs-treated rats alone showed multiple tissue alterations described by massive intrahepatic necrosis, fibrous tissue proliferation, mononuclear inflammatory cell infiltration, degradative hepatocytes, and macrovesicular steatosis. Nevertheless, in AFs-treated groups fed on supplemented diets with RWRs, liver hepatocytes appeared to gradually improve with increasing the level of RWRs added, to be approximately normal, especially with higher levels (20%). In conclusion, results discovered that RWRs reduced the toxic effect of aflatoxins. Accordingly, regular intake of RWRs may be beneficial to prevent the consequences of injury from toxicity by AFs. This action may be due to RWRs wide range of content of flavonoids and phenolics as bioactive compounds.