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350487

IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA

Article

Last updated: 25 Dec 2024

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Abstract

In human steroid-sensitive tissue, Estrogen receptors (ERs) have been demonstrated at the mRNA and/or protein levels by using molecular biology and immunohistochemistry techniques. Estrogen receptors are present in endometrial hyperplasia and neoplastic endometrium. The present work aimed to compare the expression of ER as a prognostic biomarker in human endometrial adenocarcinoma versus benign tumors and normal endometrial tissues as well as their correlation with different pathological and histological parameters. The immunohistochemical technique was used to examine the expression of ER in normal, benign as well as in endometrial adenocarcinoma. Present results showed higher expression of ER in endometrial adenocarcinoma compared to normal and benign endometrial tissues.

DOI

10.21608/jmals.2024.350487

Keywords

ER prognostic marker, Estrogen Receptors, Endometrial adenocarcinoma

Authors

First Name

Saeed

Last Name

Mohamed

MiddleName

Mahmoud Saeed

Affiliation

Assistant Professor of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, West Kurdofan University, Sudan.

Email

saeedmahmoud999@yahoo.com

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Orcid

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First Name

Afaf

Last Name

Amin

MiddleName

Mosaad

Affiliation

Professor of Histochemistry and Cell Biology Department, Medical Research Institute, University of Alexandria, Egypt.

Email

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City

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Orcid

-

First Name

Aisha

Last Name

salih

MiddleName

Mohmmed Osman

Affiliation

Assistant Professor of Biology and Biotechnology Department (Animal Physiology), Faculty of Science and Technology, Al Neelain University, Khartoum-Sudan

Email

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City

-

Orcid

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First Name

Sabah

Last Name

Al-Qadasi

MiddleName

Ali Mugahed

Affiliation

Assistant Professor of Histology, Anatomy and Histology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.

Email

-

City

-

Orcid

-

First Name

Roa

Last Name

Sultan

MiddleName

Mohmed Mahmoud

Affiliation

Lecturer of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum- Sudan.

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-

City

-

Orcid

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Volume

6

Article Issue

2

Related Issue

47169

Issue Date

2024-06-01

Receive Date

2024-02-03

Publish Date

2024-06-01

Page Start

101

Page End

114

Print ISSN

2636-4093

Online ISSN

2636-4107

Link

https://jmals.journals.ekb.eg/article_350487.html

Detail API

https://jmals.journals.ekb.eg/service?article_code=350487

Order

350,487

Type

Original Article

Type Code

1,104

Publication Type

Journal

Publication Title

Journal of Medical and Life Science

Publication Link

https://jmals.journals.ekb.eg/

MainTitle

IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA

Details

Type

Article

Created At

25 Dec 2024