Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. Cathepsin D (Cath-D) is a soluble lysosomal aspartyl glycoprotease that can degrade the protein components of the matrix and free growth factors therein embedded, thus favoring tumor growth, invasion, and angiogenesis. The present work aimed to compare the expression of GP88 and Cath-D as novel prognostic biomarkers in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues as well as their correlation with different pathological and histological parameters. The immunohistochemical technique was used to examine the expression of GP88 and Cath-D in normal, benign, and IDC. Present results showed higher expression of GP88, and Cath-D in IDC compared to normal and benign breast tissues.