Cancer is defined as the accumulation of abnormal cells that are formed by cell proliferation and cause damage to all organs. According to reports from the World Health Organization, the number of people infected with this disease exceeds ten million, Essential oils are a blend of several non-terpenoid chemicals that are beneficial in food flavoring, medications, and cosmetics. This study focused on studying the preventive role of essential oils as a treatment for cancer.  This study's goal was to ascertain the effects of Essential oils (orange peels) against Ehrlich Ascites Carcinoma-induced cardiac toxicity. 40 mice were divided into four groups at random (G1, control; G2, Essential oils (orange peels) (25 mg/kg bw/day) orally for 2 weeks; G3, EAC and G4, EAC + Essential oils (orange peels)). Current findings showed, that EAC induced a significant elevation in creatine kinase myoglobin (CK-MB), cholesterol, triglycerides, potassium, and sodium, a significant increase in serum AFP, CEA, and Desmine expressions when compared to Essential oils (orange peels), and control groups. EAC + Essential oils (orange peels) adjust these modifications. EAC-induced cardiac dysfunction and Essential oils (orange peels) can improve cardiac functions, and post-treated EAC with Essential oils (orange peels) improved, AFP and CEA Levels and Desmine expressions. It is possible to utilize essential oils (orange peels) as a supportive treatment for cardiac ascites caused by hepatocellular carcinoma, Schistosoma, and hepatitis.