The present study was carried out on marine edible sea urchin Paracentrotus lividus which are predominant in the local aquatic fauna in Egypt. The present research was conducted to extract carotenoids from soft parts of sea urchin and estimate their activity on obese mice that receive high-fat diet HFD as a protective and curative effect. The results showed the effect of carotenoid in a protective group, significantly reduced plasma triglyceride, HDL, and total cholesterol also lowered blood glucose levels. Oral administration of carotenoid extracts substantially decreased the rate of gaining weight and recovered lipid profile levels to normal as compared to the control group with improvement of liver function tests in serum and oxidative stress parameters in liver tissue. Histological differences in liver tissues revealed that the extracts protected the liver tissue from adiposeness by high-fat diet HFD fed.
   In conclusion, this study demonstrates the potential anti-obesity effects of the carotenoid administration in mice supplied with a diet rich in fat and obese mice. The findings suggest that the bioactive compound carotenoid as astaxanthin supplementation extracted from Paracentrotus lividus exhibits anti-obesity activity that can improve lipid profiles, glucose metabolism, and antioxidant status.