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308224

Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol

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Last updated: 25 Dec 2024

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Abstract

Paracetamol is a widely used analgesic and antipyretic drug, but its long-term usage has been associated with potential toxicity. The goal of this study was to investigate how frankincense oil prevents paracetamol toxicity. The study included twenty male albino rats divided into four groups: (G1) control, (G2) paracetamol, (G3) frankincense oil, and (G4) paracetamol + frankincense oil. For three days, 1000 mg/kg paracetamol was given orally, while frankincense oil was given orally at a dosage of 1000 mg/kg concurrently with paracetamol. Hematological parameters, lipid profile, cardiac markers, pancreatic function, blood antioxidant capacity, myeloperoxidase activity, blood, spleen, pancreas, heart, and lung histopathology were evaluated.
Paracetamol caused oxidative stress, hematotoxicity, dyslipidemia, myocardial damage, pancreatic dysfunction, spleen alterations, and lung tissue damage. However, coadministration of paracetamol and frankincense oil protected against these effects by boosting antioxidant capacity, improving hematological parameters, preserving pancreatic function, enhancing lipid profiles, preserving spleen morphology, and preventing lung damage, likely due to the antioxidant properties of frankincense oil.
In conclusion, this study highlights the potential of frankincense oil as a counteractive agent for paracetamol-induced organ toxicity. The findings suggest that frankincense oil supplementation may mitigate the adverse effects of paracetamol, offering a potential therapeutic approach to enhance overall health outcomes.

DOI

10.21608/jmals.2023.308224

Keywords

Paracetamol, toxicity, Frankincense Oil

Authors

First Name

Aml

Last Name

Talaat

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-

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

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-

First Name

Yomna

Last Name

Elgendy

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

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-

Orcid

-

First Name

Heba

Last Name

Mohamed

MiddleName

F.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

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-

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-

Orcid

-

First Name

Nouran

Last Name

Saed

MiddleName

M

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

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-

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-

Orcid

-

First Name

Noran

Last Name

Abd Elrouf

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

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-

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-

Orcid

-

First Name

Hend

Last Name

Elgendy

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

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-

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-

Orcid

-

First Name

Hagar

Last Name

Elbalakousy

MiddleName

H.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

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-

Orcid

-

First Name

Nourhan

Last Name

El hantoshy

MiddleName

N.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

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-

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-

Orcid

-

First Name

Mohammed

Last Name

Elmezaien

MiddleName

S.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

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-

Orcid

-

First Name

Youssef

Last Name

Sayed

MiddleName

M.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

Yosry

Last Name

El . Hekal

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

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-

City

-

Orcid

-

First Name

Mohamed

Last Name

Gabr

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

-

City

-

Orcid

-

First Name

1. Nada

Last Name

Badr

MiddleName

S.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

nada.shaaban@sci.dmu.edu.eg

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-

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-

Volume

5

Article Issue

3

Related Issue

43640

Issue Date

2023-09-01

Receive Date

2023-04-14

Publish Date

2023-09-01

Page Start

155

Page End

175

Print ISSN

2636-4093

Online ISSN

2636-4107

Article File

JMALS_Volume 5_Issue 3_Pages 155-175.pdf

PDF . 3.0MB

Link

https://jmals.journals.ekb.eg/article_308224.html

Detail API

https://jmals.journals.ekb.eg/service?article_code=308224

Order

308,224

Type

Original Article

Type Code

1,104

Publication Type

Journal

Publication Title

Journal of Medical and Life Science

Publication Link

https://jmals.journals.ekb.eg/

MainTitle

Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol

Details

Type

Article

Created At

25 Dec 2024