Gout as a disease of kings is one of the oldest joint diseases known to humans and a common metabolic disease that is caused by high serum uric acid levels. It is considered to be closely associated with the development of many chronic diseases, such as obesity, hypertension, hyperlipemia, diabetes, and cardiovascular disorders. The current study aims to investigate the effects of bioactive compounds from chicory as natural remedies for the management of hyperuricemia in different concentrations (5,15,20 g) of dry leaves of chicory from two sources (Egypt and Jordan) on gout and  the possible induced changes on kidney function, polyphenol oxidase of albino rats. Sixty adult male Albino rats weighing about (140±10) g were taken and divided into 10 groups, each with six rats. The first group is the negative control (-) and fed on normal diet for 8 weeks. The other groups received injections with Mono-Sodium Urate (MSU) crystal and different dose of chicory. The results showed that the positive control group (+) and all groups had a significant increase in serum kidney function test, uric acid, creatinine, urea and polyphenol oxidase as compared to the negative control group (-) and as well as damage in the kidney and bow tissue, however the other groups that fed on different ratios of chicory showed improvement in kidney function, polyphenol oxidase compared to the positive control group (+). The authors concluded that Chicory can be used in the management of hyperuricemia and gout