Background: Sexual dimorphism is crucial for person identification, distinguishing males from females. The mandible, the most dimorphic skull bone, is easily imagined using Cone Beam Computed Tomography (CBCT). Skeletal structures vary among populations, requiring specific standards for accuracy. Aim of the work: To provide a reliable method and accurate determination for sex identification. Subjects and methods: The study comprised 260 full skull CBCT radiographs, it was carried out in Oral Radiology Department at Faculty of Dentistry in Suez Canal University (SCU), twelve parameters were measured, maximum ramus length (Max. RL), mandibular base length (MBL), gonial angle (GA), body height at mental foramen (BHMF), maximum ramus breadth (Max. RB), minimum ramus breadth (Min. RB), mandibular notch breadth (MNB), mandibular length projection (MLP), bi- coronoid breadth (BCB), bi- mental length (BML), bi- gonial breadth (BGB) and bi- condylar breadth (BCoB). Results: Males were significantly larger in all measurements except for the gonial angle which was larger in females. Using receiver operating characteristics (ROC) analysis, BGB followed by BCB and BCoB provided sex discrimination accuracy of 76.16% and 73.46% respectively. 90% of the males and 89.2% of the females were properly identified by the binary logistic regression (BLR) model, yielding an overall classification accuracy of 89.6%. The regression formula yielded an accuracy of 89.23%, specificity of 88.46% and sensitivity of 90%. Conclusion and recommendations: Mandible measurements can be used to correctly detect a person's sex, and it is an excellent bone for forensic examination.