Background: Teaching and practicing medical ethics to medical students is not only a fundamental part of medical education, but it is also crucial to the advancement of the bio-psycho-social medical mode of modern medicine. Aim of the work: The present work aimed to assess perception of house officers about medical ethics and measure their knowledge about the subject with comparison between two batches of training doctors from two different educational programs (six plus one and five plus two) in Sohag Faculty of Medicine.  Subjects and Methods: A comparative cross-sectional study from two different educational programs [five plus two (group 1) and six plus one (group 2)] in Sohag University Hospital. This study was conducted over 3 months duration via an online survey using a Google Form for a questionnaire based on the CEM (Code of Medical Ethics) and modified from tools that have been verified in literature, 376 of participants included. Results: The study showed that more than 50% of both groups didn't know the code of medical ethics or what their university's ethical committee was for; a considerable percent of both groups didn't know how to deal with clinical cases in their practical life. Conclusion: From the present study it was released that house officers of both groups of study had defective knowledge in medical ethics and clinical dilemmas, indicating insufficient medical curriculum during basic study. Recommendation: Modification of the current course of basic medical ethics. The need of more post graduate ethical courses and seminars with discussion of different common practical cases.