Methanol intoxication is a serious health problem that affects people all over the world causing high morbidity and mortality. This study aimed to determine predictors of mortality and to evaluate the role of Sequential Organ Failure Assessment score (SOFA) and Poison Severity Score (PSS) as early outcome indicators among patients with acute methanol intoxication. Subjects and methods: A retrospective and prospective study included 64 patients with acute methanol intoxication presented to The Poison Control Center of Ain Shams University Hospitals from January 2021 to December 2022. Data such as demographics, exposure history, clinical findings, and results of investigations were gathered and the patients were scored on SOFA score and PSS.
Results: Out of 64 included patients, 22 patients were non-survivors. The mean systolic and diastolic blood pressure as well as temperature, GCS, pH, and Hco3 were significantly lower among non-survivors with significantly higher respiratory rate, base deficit, random blood sugar, blood urea nitrogen, creatinine levels, platelet count, P.T., PTT, INR, PSS and SOFA scores than survivors. Conclusion: Systolic blood pressure ≤90 mmHg, diastolic blood pressure ≤60 mmHg, Temperature ≤36, Respiratory rate >28 cycle/min, presence of seizures and shock, GCS≤9, Coma on admission, PH≤7.01, HCO3≤7 mmol/L, Base deficit >20.7 mmol/L, blood urea nitrogen >30 mg/dl, Creatinine>1.6 mg/dl, random blood sugar >180 mg/dl, Platelet count >345, INR>1.25, Prothrombin time >15 seconds, partial thromboplastin time >35 seconds, need for mechanical ventilation, severe PSS and SOFA >5 are significant mortality predictors. However, the SOFA score is the early accepting and most accurate mortality predictor.