This study was conducted in Bardawill lagoon during the fishing season 2021 on 958 specimens of the gilthead seabream Sparus aurata collected from two regions in the lagoon (R1 & R2), the first located in the middle of the lagoon in front of the artificial opening located directly under the influence of the waters of the Mediterranean Sea, and the second located in the southwest of the lagoon far from the influence of the waters of the Mediterranean Sea. The results indicated that R1 is characterized by its low water salinity, high dissolved oxygen and depth in comparisons with R2. For specimens from R1 and R2, the respective estimated b values of the length-weight relationship were 2.9542 and 3.0036 ,  von Bertlanffy growth parameters (L∞ and K) were  33.6 cm and 29.4 cm and 0.29 and 0.87 year⁻¹. As well as their values of growth performance in length index () were 5.7911 and 6.622). Also, their values of the Hepato-Somatic and Gut Repletion Indices were different. The results indicated that  the  environmental conditions  in R1 in the middle of the lagoon and near the point of contact with the Mediterranean Sea provide more suitable conditions for seabream growth compared to those from the southwestern region of the lagoon. Therefore, the study recommends developing and improving the environment of the southwestern region of Bardawil Lagoon for the purpose of developing seabream stock with continuous keeping the inlets open.