ABSTRACT Water samples were collected from 24 locations during 4 seasons along the extends of Damietta and Rosetta branches during 2010-2011. The main objective of this study is to determine the factors affecting on the distribution dynamics of the investigated metals (Fe, Mn, Cu, Zn, CO, Ni, Pb and Cd) in the water samples from the two River Nile branches. The present results showed that, Rosetta branch was highly polluted by the effluents discharged to the branch from the drain and from industrial area at Kafr El-Zayat city. Also, the highest contents of heavy metals were recorded in the cold season. The results showed that there was high seasonal and regional fluctuation in concentrations of the metals depending on the quantity and quality of the discharged effluents.